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Review
. 2018 Feb;7(2):69-81.
doi: 10.1002/psp4.12269. Epub 2017 Dec 14.

Translational Systems Pharmacology Studies in Pregnant Women

Sara K Quinney  1   2 , Rakesh Gullapelli  3 , David M Haas  1   2
Affiliations
Review

Translational Systems Pharmacology Studies in Pregnant Women

Sara K Quinney et al. CPT Pharmacometrics Syst Pharmacol. 2018 Feb.

Abstract

Pregnancy involves rapid physiological adaptation and complex interplay between mother and fetus. New analytic technologies provide large amounts of genomic, proteomic, and metabolomics data. The integration of these data through bioinformatics, statistical, and systems pharmacology techniques can improve our understanding of the mechanisms of normal maternal physiologic changes and fetal development. New insights into the mechanisms of pregnancy-related disorders, such as preterm birth (PTB), may lead to the development of new therapeutic interventions and novel biomarkers.

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Figures

Figure 1
Figure 1
PubMed citations per year relating to (a) genomic, (b) proteomic, and (c) metabolomic studies in pregnancy (gray line). For comparison, the black line represents all genomic, proteomic, or metabolomics studies in PubMed and the dashed line indicates those studies relating to oncology.
Figure 2
Figure 2
Complex pathophysiology of preterm birth (PTB). Systems pharmacology approaches can integrate data from genomic, proteomic, metabolomic, clinical, in vitro, and animal studies to improve understanding and optimize therapy for PTB.
See this image and copyright information in PMC

References

    1. Bhattacharya, S. et al Inherited predisposition to spontaneous preterm delivery. Obstet. Gynecol. 115, 1125–1133 (2010). - PubMed
    1. Sorger, P.K. et al Quantitative and systems pharmacology in the post‐genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms. An NIH white paper by the QSP workshop group – October, 2011 (ed. Ward, R.) (NIH Bethesda, Bethesda, MD, 2011).
    1. Tracy, T.S. , Venkataramanan, R. , Glover, D.D. & Caritis, S.N. ; National Institute for Child Health and Human Development Network of Maternal‐Fetal‐Medicine Unites. Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A activity) during pregnancy. Am. J. Obstet. Gynecol. 192, 633–639 (2005). - PubMed
    1. Anderson, G.D. Pregnancy‐induced changes in pharmacokinetics: a mechanistic‐based approach. Clin. Pharmacokinet. 44, 989–1008 (2005). - PubMed
    1. Mendenhall, H.W. Serum protein concentrations in pregnancy. I. Concentrations in maternal serum. Am. J. Obstet. Gynecol. 106, 388–399 (1970). - PubMed

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