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. 2018 Feb;46(2):811-818.
doi: 10.1177/0300060517722698. Epub 2017 Sep 14.

Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus

Manar Al-Lawama  1 , Iyad Alammori  1 , Tariq Abdelghani  1 , Eman Badran  1
Affiliations

Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus

Manar Al-Lawama et al. J Int Med Res. 2018 Feb.

Abstract

Objective This study was performed to investigate the safety and efficacy of oral paracetamol versus oral ibuprofen in the treatment of patent ductus arteriosus (PDA) in premature infants. Methods Premature infants with PDA with a gestational age of ≤32 weeks or birth weight of ≤1500 g were included in this randomized study. Results A total of 120 premature infants fulfilled the inclusion criteria. Of these 120 infants, 34 fulfilled the treatment criteria and 22 were finally randomized. We found no significant difference in the mortality or primary closure rates between the two groups. We also found no significant difference in the short-term neonatal outcomes. Conclusions Either oral paracetamol or oral ibuprofen can be used safely and effectively to treat PDA in premature infants.

Keywords: Premature infants; ibuprofen; paracetamol; patent ductus arteriosus; randomized study; safety.

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Figure 1.
Study flow diagram
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