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. 2018 Feb;46(2):811-818.
doi: 10.1177/0300060517722698. Epub 2017 Sep 14.

Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus

Manar Al-Lawama  1 , Iyad Alammori  1 , Tariq Abdelghani  1 , Eman Badran  1
Affiliations

Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus

Manar Al-Lawama et al. J Int Med Res. 2018 Feb.

Abstract

Objective This study was performed to investigate the safety and efficacy of oral paracetamol versus oral ibuprofen in the treatment of patent ductus arteriosus (PDA) in premature infants. Methods Premature infants with PDA with a gestational age of ≤32 weeks or birth weight of ≤1500 g were included in this randomized study. Results A total of 120 premature infants fulfilled the inclusion criteria. Of these 120 infants, 34 fulfilled the treatment criteria and 22 were finally randomized. We found no significant difference in the mortality or primary closure rates between the two groups. We also found no significant difference in the short-term neonatal outcomes. Conclusions Either oral paracetamol or oral ibuprofen can be used safely and effectively to treat PDA in premature infants.

Keywords: Premature infants; ibuprofen; paracetamol; patent ductus arteriosus; randomized study; safety.

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Figures

Figure 1.
Figure 1.
Study flow diagram
See this image and copyright information in PMC

References

    1. Sellmer A, Bjerre JV, Schmidt MR, et al. Morbidity and mortality in preterm neonates with patent ductus arteriosus on day 3. Arch Dis Child Fetal Neonatal Ed 2013; 98: 505–510. - PubMed
    1. Sallmon H Koehne P andHansmann G.. Recent Advances in the Treatment of Preterm Newborn Infants with Patent Ductus Arteriosus. Clin Perinatol 2016; 43: 113–129. - PubMed
    1. Van Overmeire B, Smets K, Lecoutere D, et al. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus 2000; 343: 674–681. - PubMed
    1. Gulack BC, Laughon MM, Clark RH, et al. Comparative effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus. Early Hum Dev 2015; 91: 725–729. - PMC - PubMed
    1. Nadir E, Kassem E, Foldi S, et al. Paracetamol treatment of patent ductus arteriosus in preterm infants. J Perinatol 2014; 34: 748–749. - PubMed

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