Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan-Mar;32(1):10-17.
doi: 10.1097/WAD.0000000000000223.

Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS)

Sandra Weintraub  1   2 , Lilah Besser  3 , Hiroko H Dodge  4   5 , Merilee Teylan  3 , Steven Ferris  6 , Felicia C Goldstein  7 , Bruno Giordani  5 , Joel Kramer  8 , David Loewenstein  9 , Dan Marson  10 , Dan Mungas  11 , David Salmon  12 , Kathleen Welsh-Bohmer  13 , Xiao-Hua Zhou  3 , Steven D Shirk  14 , Alireza Atri  15   16   17 , Walter A Kukull  3 , Creighton Phelps  18 , John C Morris  19
Affiliations

Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS)

Sandra Weintraub et al. Alzheimer Dis Assoc Disord. 2018 Jan-Mar.

Abstract

Introduction: The neuropsychological battery of the Uniform Data Set (UDSNB) was implemented in 2005 by the National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance in dementia and mild cognitive impairment due to Alzheimer Disease. This paper describes a revision, the UDSNB 3.0.

Methods: The Neuropsychology Work Group of the NIA Clinical Task Force recommended revisions through a process of due diligence to address shortcomings of the original battery. The UDSNB 3.0 covers episodic memory, processing speed, executive function, language, and constructional ability. Data from 3602 cognitively normal participants in the National Alzheimer Coordinating Center database were analyzed.

Results: Descriptive statistics are presented. Multivariable linear regression analyses demonstrated score differences by age, sex, and education and were also used to create a normative calculator available online.

Discussion: The UDSNB 3.0 neuropsychological battery provides a valuable non proprietary resource for conducting research on cognitive aging and dementia.

PubMed Disclaimer

Conflict of interest statement

S.W.: is participating in clinical trials of antidementia drugs from Eli Lilly and Company. K.W.-B.: received honoraria from Merck, Roche,T3D, Diffusion, and Biogen Companies. K.W.-B. is currently receiving funding from Takeda Pharmaceutical Company in her role as the Neuropsychology Lead for the TOMMORROW clinical trial program. D.M.: serves as a consultant for Janssen. Neither J.C.M. nor his family owns stock or has equity interest (outside of mutual funds or other externally directed accounts) in any pharmaceutical or biotechnology company. J.C.M. is currently participating in clinical trials of antidementia drugs from Eli Lilly and Company, Biogen, and Janssen. J.C.M. serves as a consultant for Lilly USA. He receives research support from Eli Lilly/Avid Radiopharmaceuticals and is funded by NIH grants #P50 AG005681; P01AG003991; P01AG026276; and UF01AG032438. The remaining authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Histograms showing score distributions for each measure on the UDSNB 3.0. From these graphs, many of the measures have a normal or near normal distribution, with the exception of the MoCA total score, the score for the copy of the Benson complex figure, and the total score for the MINT. Immed. indicates immediate; MINT, multilingual naming test; MoCA, Montreal Cognitive Assessment; Paraph., paraphrase.
See this image and copyright information in PMC

References

    1. Beekly DL, Ramos EM, Lee WW, et al. The National Alzheimer’s Coordinating Center (NACC) database: the uniform data set. Alzheimer Dis Assoc Disord. 2007;21:249–258. - PubMed
    1. Weintraub S, Salmon D, Mercaldo N, et al. The Alzheimer’s Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery. Alzheimer Dis Assoc Disord. 2009;23:91–101. - PMC - PubMed
    1. Morris JC. The clinical dementia rating (CDR): current version and scoring rules. Neurology. 1993;43:2412–2414. - PubMed
    1. Morris JC, Weintraub S, Chui HC, et al. The uniform data set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers. Alzheimer Dis Assoc Disord. 2006;20:210–216. - PubMed
    1. Beekly DL, Ramos EM, van Belle G, et al. The National Alzheimer’s Coordinating Center (NACC) Database: an Alzheimer disease database. Alzheimer Dis Assoc Disord. 2004;18:270–277. - PubMed

Publication types

Grants and funding