Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Dec 15;358(6369):1381-1382.
doi: 10.1126/science.aar3895.

Closing the tubulin detyrosination cycle

Anna Akhmanova  1 , Helder Maiato  2   3   4
Affiliations
Comment

Closing the tubulin detyrosination cycle

Anna Akhmanova et al. Science. .
No abstract available

PubMed Disclaimer

Figures

Figure
Figure
Freshly translated α-tubulin contains a C-terminal tyrosine residue. After forming a dimer with β-tubulin, it assembles into microtubules. Vasohibin-SVBP complex removes C-terminal tyrosine residues from tubulin polymers and thus generates detyrosinated microtubules. When these microtubules disassemble, detyrosinated tubulin can be re-tyrosinated by tyrosine-tubulin ligase.
See this image and copyright information in PMC

Comment on

  • Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.
    Aillaud C, Bosc C, Peris L, Bosson A, Heemeryck P, Van Dijk J, Le Friec J, Boulan B, Vossier F, Sanman LE, Syed S, Amara N, Couté Y, Lafanechère L, Denarier E, Delphin C, Pelletier L, Humbert S, Bogyo M, Andrieux A, Rogowski K, Moutin MJ. Aillaud C, et al. Science. 2017 Dec 15;358(6369):1448-1453. doi: 10.1126/science.aao4165. Epub 2017 Nov 16. Science. 2017. PMID: 29146868
  • Vasohibins encode tubulin detyrosinating activity.
    Nieuwenhuis J, Adamopoulos A, Bleijerveld OB, Mazouzi A, Stickel E, Celie P, Altelaar M, Knipscheer P, Perrakis A, Blomen VA, Brummelkamp TR. Nieuwenhuis J, et al. Science. 2017 Dec 15;358(6369):1453-1456. doi: 10.1126/science.aao5676. Epub 2017 Nov 16. Science. 2017. PMID: 29146869

References

    1. Gadadhar S, Bodakuntla S, Natarajan K, Janke C. J Cell Sci. 2017;130:1347. - PubMed
    1. Arce CA, Rodriguez JA, Barra HS, Caputo R. Eur J Biochem. 1975;59:145. - PubMed
    1. Raybin D, Flavin M. Biochem Biophys Res Commun. 1975;65:1088. - PubMed
    1. Hallak ME, Rodriguez JA, Barra HS, Caputto R. FEBS Lett. 1977;73:147. - PubMed
    1. Ersfeld K, Wehland J, Plessmann U, Dodemont H, Gerke V, Weber K. J Cell Biol. 1993;120:725. - PMC - PubMed