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Editorial
. 2017 Dec 14;9(12):2467-2468.
doi: 10.18632/aging.101349.

FOXO3 cell resilience gene neighborhood

Timothy A Donlon  1 , Bradley J Willcox  1 , Brian J Morris  1   2
Affiliations
Editorial

FOXO3 cell resilience gene neighborhood

Timothy A Donlon et al. Aging (Albany NY). .
No abstract available

Keywords: FOXO3; fluorescent in situ hybridization; gene-gene interactions; healthy aging; longevity.

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Figures

Figure 1
Figure 1. Dynamics of FOXO3 in lymphoblastoid cell lines
Top: Schematic depicting results of separate FISH experiments (HACE1-FOXO3-LAMA4 and ATG5-FOXO3-AMD1) in which, in response to stress (200 μM H2O2 and serum deprivation), FOXO3 moved towards the most distant flanking genes (HACE1 and LAMA4, located 3.6 and 3.7 Mb, respectively, from FOXO3) in the 46-gene neighbourhood, as well as towards more proximally located flanking genes (ATG5 and AMD1, located 2.1 and 2.3 Mb, respectively, from FOXO3), resulting in the formation of a tight transcription complex. Bottom: FOXO3 mRNA expression was greater for cell lines containing the longevity-associated G allele of SNP rs2802292 (mean ± SE; P < 0.001).
See this image and copyright information in PMC

References

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    1. Donlon TA, et al. Aging Cell. 2017;16:1016–25. https://doi.org/10.1111/acel.12625 - DOI - PMC - PubMed
    1. Morris BJ. Circ Cardiovasc Genet. 2017;10:e001943. https://doi.org/10.1161/CIRCGENETICS.117.001943"> - DOI - PubMed
    1. Boyle EA, et al. Cell. 2017;169:1177–86. https://doi.org/10.1016/j.cell.2017.05.038 - DOI - PMC - PubMed
    1. Bekris LM, et al. J Hum Genet. 2012;57:18–25. https://doi.org/10.1038/jhg.2011.123 - DOI - PMC - PubMed

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