doi: 10.1016/j.cell.2017.12.002.
CD19 CAR T Cells
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- PMID: 29245005
- DOI: 10.1016/j.cell.2017.12.002
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CD19 CAR T Cells
Cell.
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Abstract
CARs are synthetic receptors that reprogram immune cells for therapeutic purposes. They comprise three canonical domains for antigen recognition, T cell activation, and costimulation. The CAR cDNA is genetically integrated in the T cell genome. Autologous CAR T cells are generated from the patient's peripheral blood T cells and expand in the recipient to eliminate the targeted tumor. To view this Bench to Bedside, open or download the PDF.
Copyright © 2017. Published by Elsevier Inc.
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