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. 2017 Dec 14;171(7):1471.
doi: 10.1016/j.cell.2017.12.002.

CD19 CAR T Cells

Michel Sadelain  1
Affiliations
Free article

CD19 CAR T Cells

Michel Sadelain. Cell. .
Free article

Abstract

CARs are synthetic receptors that reprogram immune cells for therapeutic purposes. They comprise three canonical domains for antigen recognition, T cell activation, and costimulation. The CAR cDNA is genetically integrated in the T cell genome. Autologous CAR T cells are generated from the patient's peripheral blood T cells and expand in the recipient to eliminate the targeted tumor. To view this Bench to Bedside, open or download the PDF.

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