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. 2017 Dec 16;17(1):772.
doi: 10.1186/s12879-017-2888-5.

Possible interference between seasonal epidemics of influenza and other respiratory viruses in Hong Kong, 2014-2017

Xueying Zheng  1   2 , Zhengyu Song  1 , Yapeng Li  1 , Juanjuan Zhang  1 , Xi-Ling Wang  3   4   5
Affiliations

Possible interference between seasonal epidemics of influenza and other respiratory viruses in Hong Kong, 2014-2017

Xueying Zheng et al. BMC Infect Dis. .

Abstract

Background: Unlike influenza viruses, little is known about the prevalence and seasonality of other respiratory viruses because laboratory surveillance for non-influenza respiratory viruses is not well developed or supported in China and other resource-limited countries. We studied the interference between seasonal epidemics of influenza viruses and five other common viruses that cause respiratory illnesses in Hong Kong from 2014 to 2017.

Methods: The weekly laboratory-confirmed positive rates of each virus were analyzed from 2014 to 2017 in Hong Kong to describe the epidemiological trends and interference between influenza viruses, respiratory syncytial virus (RSV), parainfluenza virus (PIV), adenovirus, enterovirus and rhinovirus. A sinusoidal model was established to estimate the peak timing of each virus by phase angle parameters.

Results: Seasonal features of the influenza viruses, PIV, enterovirus and adenovirus were obvious, whereas annual peaks of RSV and rhinovirus were not observed. The incidence of the influenza viruses usually peaked in February and July, and the summer peaks in July were generally caused by the H3 subtype of influenza A alone. When influenza viruses were active, other viruses tended to have a low level of activity. The peaks of the influenza viruses were not synchronized. An epidemic of rhinovirus tended to shift the subsequent epidemics of the other viruses.

Conclusion: The evidence from recent surveillance data in Hong Kong suggests that viral interference during the epidemics of influenza viruses and other common respiratory viruses might affect the timing and duration of subsequent epidemics of a certain or several viruses.

Keywords: Influenza; Interference; Respiratory viruses; Seasonal epidemics.

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Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Weekly number of specimens and positivity rates of laboratory-confirmed cases for six viruses in Hong Kong, 2014–2017
Fig. 2
Fig. 2
Time series of weekly laboratory-confirmed positive rates of influenza viruses and parainfluenza viruses (PIV) with subtypes in Hong Kong, 2014–2017. a influenza viruses; b parainfluenza viruses
Fig. 3
Fig. 3
Three-week moving averages of weekly positive rates for six viruses in Hong Kong, 2014–2017. a influenza viruses; b respiratory syncytial virus; c parainfluenza viruses; d rhinovirus; e adenovirus; f enterovirus
Fig. 4
Fig. 4
Estimates for annual and semi-annual peak timings of six viruses in Hong Kong, 2014–2017. Open circles represent point estimates from seasonal regression models and horizontal lines represent 95% block-bootstrap confidence intervals based on 1000 replications
See this image and copyright information in PMC

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