GAPs in early life facilitate immune tolerance

Ziad Al Nabhani^{1

2}, Gérard Eberl^{3

2}

Affiliations

¹ Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France.
² INSERM U1224, 75724 Paris, France.
³ Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France. gerard.eberl@pasteur.fr.

Comment

Ziad Al Nabhani et al. Sci Immunol. 2017.

. 2017 Dec 15;2(18):eaar2465.

doi: 10.1126/sciimmunol.aar2465.

Ziad Al Nabhani^{1

2}, Gérard Eberl^{3

2}

¹ Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France.
² INSERM U1224, 75724 Paris, France.
³ Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France. gerard.eberl@pasteur.fr.

Abstract

Goblet cells deliver microbial antigens to generate regulatory T cells before and during weaning to induce long-term tolerance to symbionts.

Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria.
Knoop KA, Gustafsson JK, McDonald KG, Kulkarni DH, Coughlin PE, McCrate S, Kim D, Hsieh CS, Hogan SP, Elson CO, Tarr PI, Newberry RD. Knoop KA, et al. Sci Immunol. 2017 Dec 15;2(18):eaao1314. doi: 10.1126/sciimmunol.aao1314. Sci Immunol. 2017. PMID: 29246946 Free PMC article.