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Multicenter Study
. 2017 Dec 14;7(12):e018094.
doi: 10.1136/bmjopen-2017-018094.

Factors associated with high levels of glycated haemoglobin in patients with type 1 diabetes: a multicentre study in Brazil

Carine Sousa Andrade  1   2 , Guilherme Sousa Ribeiro  1   3 , Carlos Antonio Souza Teles Santos  1   4 , Raimundo Celestino Silva Neves  1 , Edson Duarte Moreira Jr  1   5
Affiliations
Multicenter Study

Factors associated with high levels of glycated haemoglobin in patients with type 1 diabetes: a multicentre study in Brazil

Carine Sousa Andrade et al. BMJ Open. .

Abstract

Objective: Long-term complications of type 1 diabetes mellitus (DM1) can be prevented with adequate glycaemic control. However, high levels of glycated haemoglobin (HbA1c) occur in 60%-90% of the patients with DM1. Thus, we aimed to investigate the role of sociodemographic, behavioural and clinical factors on the HbA1c levels of patients with DM1 in Brazil.

Design, setting and participants: A cross-sectional study was conducted in ambulatory patients with DM1 aged ≥18 years from 10 Brazilian cities. Sociodemographic, behavioural and clinical data were obtained through interviews.

Main outcome measures: HbA1c level was measured by liquid chromatography. Hierarchical multiple variable linear regression models were used to identify factors correlated with high levels of HbA1c.

Results: Of 979 patients with DM1, 63.8% were women, and the mean age was 40 (SD 14.6) years. The mean HbA1c level was 9.4% (SD 2.2%), and 89.6% of the patients had HbA1c ≥7.0%. Factors independently correlated with increased HbA1c levels included: lower education, non-participation in diabetes classes/lecture during the year before, having a self-perception of poor adherence to diet and insulin, not having private medical care and not measuring the HbA1c levels in the prior year. Of note, poor adherence to diet and insulin were the independent factors most strongly associated with high levels of HbA1c (mean increment in HbA1c levels of 0.88% and 1.25%, respectively).

Conclusion: Poor glycaemic control, which is common among Brazilian patients with DM1, is associated with lower education, self-perception of insufficient adherence to diet and insulin and inadequate monitoring of HbA1c levels. Specific actions, particularly those targeting improving adherence to diet and insulin, may contribute to successful management of patients with DM1.

Keywords: Glycaemic control; epidemiology; glycated Haemoglobin; type 1 diabetes.

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Conflict of interest statement

Competing interests: EDM was a consultant for Pfizer Inc.

Figures

Figure 1
Figure 1
Hierarchical model for determinants of high levels of HbA1c in patients with type 1 diabetes. HbA1c, glycated haemoglobin.
See this image and copyright information in PMC

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