Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2017 Dec 14;7(12):e019317.
doi: 10.1136/bmjopen-2017-019317.

Protocol for the ROBUST (Registry Of type B aortic dissection with the Utility of STent graft) study: an ambispective, multicentre, open cohort study

Dan Rong  1 , Yangyang Ge  1 , Yan Xue  2 , Feng Liu  1   3 , Kai Lu  1   4 , Peng Liu  1   5 , Lei Zhang  3 , Xiaohu Ge  6 , Jianhang Miu  7 , Linkun Zhong  7 , Weidong Fan  8 , Hongpeng Zhang  1 , Xin Jia  1 , Xiaohui Ma  1 , Jiang Xiong  1 , Xiaoping Liu  1 , Wei Guo  1
Affiliations
Multicenter Study

Protocol for the ROBUST (Registry Of type B aortic dissection with the Utility of STent graft) study: an ambispective, multicentre, open cohort study

Dan Rong et al. BMJ Open. .

Abstract

Introduction: Thoracic endovascular aortic repair (TEVAR) is widely used for type B aortic dissection, although with satisfactory outcome in a limited proportion of patients. To better inform patient prognostication, the Registry Of type B aortic dissection with the Utility of STent graft (ROBUST) study aims to identify imaging-based predictors of post-TEVAR adverse outcomes up to 10-year follow-up.

Methods and analysis: ROBUST is designed as an ambispective, multicentre, open cohort study. All patients undergoing TEVAR from 1 January 2008 to 1 July 2027 at participating centres will be invited to join the study. It is conservatively estimated that over 2000 patients will join the study. Data on demographics, disease history, procedural details, imaging features and follow-up will be collected after discharge. Cox proportional-hazards analysis will be used to identify independent predictors of primary outcomes. Stratification analysis will be performed to identify which subgroup of patients would benefit the most from TEVAR.

Ethics and dissemination: The protocol has been approved by the ethics committee of the coordinating centre. Findings will be disseminated in professional peer-reviewed journals to promote understanding of the rehabilitation process.

Trial registration number: ChiCTR-POC-17011726; Pre-results.

Keywords: imaging features; patient prognostication; thoracic endovascular aortic repair; type B aortic dissection.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Similar articles

See all similar articles

References

    1. Acierno L. The history of cardiology. New York: Parthenon Publishing Group, 1994.
    1. Hagan PG, Nienaber CA, Isselbacher EM, et al. . The international registry of acute aortic dissection (IRAD): new insights into an old disease. JAMA 2000;283:897–903. - PubMed
    1. Warden HE, COHEN M, READ RC, et al. . Controlled cross circulation for open intracardiac surgery: physiologic studies and results of creation and closure of ventricular septal defects. J Thorac Surg 1954;28:331–41. - PubMed
    1. Fattori R, Tsai TT, Myrmel T, et al. . Complicated acute type B dissection: is surgery still the best option?: a report from the international registry of acute aortic dissection. JACC Cardiovasc Interv 2008;1:395–402. 10.1016/j.jcin.2008.04.009 - DOI - PubMed
    1. Dake MD, Kato N, Mitchell RS, et al. . Endovascular stent-graft placement for the treatment of acute aortic dissection. N Engl J Med 1999;340:1546–52. 10.1056/NEJM199905203402004 - DOI - PubMed

Publication types

LinkOut - more resources