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Review
. 2018 Jan;281(1):169-178.
doi: 10.1111/imr.12610.

Regulation and function of interleukin-36 cytokines

Esen Yonca Bassoy  1 , Jennifer E Towne  2 , Cem Gabay  1
Affiliations
Review

Regulation and function of interleukin-36 cytokines

Esen Yonca Bassoy et al. Immunol Rev. 2018 Jan.

Abstract

The interleukin (IL)-36 cytokines include 3 agonists, IL-36α, IL-36β, and IL-36γ that bind to a common receptor composed of IL-36R and IL-1RAcP to stimulate inflammatory responses. IL-36Ra is a natural antagonist that binds to IL-36R, but does not recruit the co-receptor IL-1RAcP and does not stimulate any intracellular responses. The IL-36 cytokines are expressed predominantly by epithelial cells and act on a number of cells including immune cells, epithelial cells, and fibroblasts. Processing of the N-terminus is required for full agonist or antagonist activity for all IL-36 members. The role of IL-36 has been extensively demonstrated in the skin where it can act on keratinocytes and immune cells to induce a robust inflammatory response that has been implicated in psoriatic disorders. Emerging data also suggest a role for this cytokine family in pulmonary and intestinal physiology and pathology.

Keywords: IL-1 family; inflammation; intestine; lung; psoriasis.

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