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. 1989 Feb;48(2):215-24.
doi: 10.1016/s0014-4835(89)80071-5.

The human lens epithelium; morphological and ultrastructural changes associated with steroid therapy

A K Karim  1 , T J Jacob, G M Thompson
Affiliations

The human lens epithelium; morphological and ultrastructural changes associated with steroid therapy

A K Karim et al. Exp Eye Res. 1989 Feb.

Abstract

A distinct disturbance to the structure of the lens epithelium was observed in cataract patients receiving steroid medication. Of those cataract patients receiving steroids, 83% exhibited a reticulated pattern of intercellular clefts compared to 5% in the control group. The reticulated pattern was shown to be due to the presence of gaps between the lateral borders of the epithelial cells by electron microscopy. A significant correlation between steroid therapy and epithelial disruption was demonstrated. The significance of such epithelial disruption to cataract formation is discussed.

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