A Peek into Parkinson's Disease Progression through Human Dopamine Neurons in a Dish
- PMID: 29248177
- DOI: 10.1016/j.tins.2017.12.001
A Peek into Parkinson's Disease Progression through Human Dopamine Neurons in a Dish
Abstract
Using induced human dopamine (DA) neurons, a study by Burbulla and colleagues demonstrated a toxic cascade of cellular dysfunctions which may underlie Parkinson's disease (PD) progression. Their findings reveal what could be the causal relationship between multiple pathogenic pathways in human neurons obtained from idiopathic and familial cases, and suggest novel targets for therapeutic intervention.
Copyright © 2017. Published by Elsevier Ltd.
Comment on
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Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.Science. 2017 Sep 22;357(6357):1255-1261. doi: 10.1126/science.aam9080. Epub 2017 Sep 7. Science. 2017. PMID: 28882997 Free PMC article.
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