Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jan;23(1):96-97.
doi: 10.1111/nep.13086.

Cabozantinib-induced renal thrombotic microangiopathy

Gaetano La Manna  1 , Olga Baraldi  1 , Valeria Corradetti  1 , Giorgia Comai  1
Affiliations
Case Reports

Cabozantinib-induced renal thrombotic microangiopathy

Gaetano La Manna et al. Nephrology (Carlton). 2018 Jan.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Light microscopy (AFOG 10×,PAS 40×) showed fibrin thrombi in glomerular capillary and arterioles and endothelial swelling in glomeruli with mesangiolysis and duplication of glomerular basement membrane and acute tubular injury with degenerating epithelium (A,B). Electron microscopy (recovered from paraffin block) disclosed fibrin thrombus in the capillary lumen (C), micro psammoma bodies in parietal cells of Bowman capsule (D) and endothelial membrane is lifted off the glomerular basal membrane by flocculent material that occupy the subendothelial space in the absence of electron‐dense deposit (E).
See this image and copyright information in PMC

References

    1. Koopman T, Niedlich‐den Herder C, Stegeman CA et al. Kidney involvement in systemic calcitonin amyloidosis associated with medullary thyroid carcinoma. Am. J. Kidney Dis. 2017; 69: 546–9. - PubMed
    1. Hoy SM. Cabozantinib: a review of its use in patients with medullary thyroid cancer. Drugs 2014; 74: 1435–44. - PubMed
    1. Merza H, Bilusic M. Current Management Strategy for Metastatic Renal Cell Carcinoma and Future Directions. Curr. Oncol. Rep. 2017; 19: 27. - PubMed
    1. Brunocilla E, Borghesi M, Schiavina R et al. Small renal masses initially managed using active surveillance: results froma a retrospective study with long term follow up. Clin. Genitourin. Cancer 2014; 12: 178–81. - PubMed
    1. Ollero M, Sahali D. Inhibition of the VEGF signalling pathway and glomerular disorders. Nephrol. Dial. Transplant. 2015; 30: 1449–55. - PubMed

MeSH terms