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Comment
. 2018 Feb;15(1):21-24.
doi: 10.1177/1740774517746622. Epub 2017 Dec 17.

TwiC or treat? Are trials within cohorts ethically defensible?

Charles Weijer  1 , Cory E Goldstein  1 , Monica Taljaard  2   3
Affiliations
Comment

TwiC or treat? Are trials within cohorts ethically defensible?

Charles Weijer et al. Clin Trials. 2018 Feb.
No abstract available

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.

Comment in

  • Rejoinder.
    Vickers A, Young-Afat D, Ehdaie B, Kim SY. Vickers A, et al. Clin Trials. 2018 Feb;15(1):25-26. doi: 10.1177/1740774517746638. Epub 2017 Dec 7. Clin Trials. 2018. PMID: 29214850 No abstract available.
  • Rejoinder.
    Kim SY, Flory J, Relton C. Kim SY, et al. Clin Trials. 2018 Feb;15(1):27-28. doi: 10.1177/1740774517746629. Clin Trials. 2018. PMID: 29400564 No abstract available.

Comment on

References

    1. Ford I, Norrie J. Pragmatic trials. N Engl J Med 2016; 375: 454–463. - PubMed
    1. Kim S, Flory J, Relton C. Ethics and practice of trials within cohorts (TwiCs): an emerging pragmatic trial design. Clin Trials, 2018; 15: 9–16. - PMC - PubMed
    1. Vickers A, Young-Afat D, Ehdaie B, et al. Just-in-time consent: the ethical case for an alternative to traditional informed consent in randomized trials comparing an experimental intervention with usual care. Clin Trials, 2018; 15: 3–8. - PMC - PubMed
    1. Relton C, Torgerson D, O’Cathain A, et al. Rethinking pragmatic randomised controlled trials: introducing the “cohort multiple randomised controlled trial” design. BMJ 2010; 340: c1066. - PubMed
    1. Council for International Organizations of Medical Sciences (CIOMS). International ethical guidelines for health-related research involving humans, https://cioms.ch/wp-content/uploads/2017/01/WEB-CIOMS-EthicalGuidelines.pdf (2016, accessed 6 September 2017).

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