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. 1989 Apr;57(4):1235-9.
doi: 10.1128/iai.57.4.1235-1239.1989.

Bacteriologic and serologic findings in experimental pyelonephritis caused by Ureaplasma urealyticum

W J Pickering  1 , D F Birch
Affiliations

Bacteriologic and serologic findings in experimental pyelonephritis caused by Ureaplasma urealyticum

W J Pickering et al. Infect Immun. 1989 Apr.

Abstract

A challenge procedure based on reflux of Ureaplasma urealyticum to the rat kidney was used to examine the disease-causing potential of this species for the upper urinary tract. Renal infection was detected 8 days after challenge in 90 to 100% of animals exposed to 10(7) ureaplasmas but was not detected in animals exposed to fewer than 10(6) microorganisms. Viable microorganisms were recoverable from more than 60% of infected animals throughout a 24-week follow-up period of study. Animals with persistent infection exhibited a humoral response involving immunoglobulin M and immunoglobulin G antibody. These results show that U. urealyticum is capable of giving rise to chronic infection in the kidneys of rats following challenge via the ascending route.

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References

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