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. 2014;4(4):e116.
doi: 10.2106/JBJS.CC.N.00103.

Malakoplakia of Bone: A Case Report and Review of the Literature

Jason L Lane  1 , Adam D Land, S Michael Thompson, Scott D Weiner
Affiliations

Malakoplakia of Bone: A Case Report and Review of the Literature

Jason L Lane et al. JBJS Case Connect. 2014.

Abstract

Case: A sixty-one-year-old woman presented with right knee pain. Imaging demonstrated osteonecrosis, pathologic fracture, and a permeative lesion. A biopsy with irrigation and debridement was performed. Cultures grew Escherichia coli, and histology showed features of malakoplakia, a rare lesion of uncertain etiology usually found in the genitourinary tract. The patient was treated successfully with antibiotics.

Conclusion: Malakoplakia, although rare, should be included in the differential diagnosis of permeative bone lesions, especially in an immunocompromised patient.

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References

    1. Michaelis L, Gutmann C. Ueber Einschlüsse in Blasentumoren. Z Klin Med. 1902;47:208-15.
    1. von Hansemann D. Ueber malakoplakie der Harnblase. Virchow Arch Path Anat. 1903;173:302-8.
    1. Wielenberg AJ, Demos TC, Rangachari B, Turk T. Malacoplakia presenting as a solitary renal mass. AJR Am J Roentgenol. 2004 Dec;183(6):1703-5.
    1. Yousef GM, Naghibi B, Hamodat MM. Malakoplakia outside the urinary tract. Arch Pathol Lab Med. 2007 Feb;131(2):297-300.
    1. Lou TY, Teplitz C. Malakoplakia: pathogenesis and ultrastructural morphogenesis. A problem of altered macrophage (phagolysosomal) response. Hum Pathol. 1974 Mar;5(2):191-207.

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