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. 2017 Sep 15;8(60):102277-102290.
doi: 10.18632/oncotarget.20925. eCollection 2017 Nov 24.

PPARG c.1347C>T polymorphism is associated with cancer susceptibility: from a case-control study to a meta-analysis

Hao Ding #  1 , Yuanmei Chen #  2 , Hao Qiu #  3 , Chao Liu  4 , Yafeng Wang  5 , Mingqiang Kang  6 , Weifeng Tang  6
Affiliations

PPARG c.1347C>T polymorphism is associated with cancer susceptibility: from a case-control study to a meta-analysis

Hao Ding et al. Oncotarget. .

Abstract

Recently, several studies suggested that PPARG c.1347C>T polymorphism was correlated with cancer risk. However, past results remained controversial. In this study, we performed a case-control study on the relationship of PPARG c.1347C>T polymorphism with risk of non-small cell lung cancer (NSCLC) and subsequently carried out a meta-analysis to further assess the association between PPARG c.1347C>T and overall cancer. In our case-control study, after adjusting by age, sex, body mass index (BMI), smoking and drinking, a tendency to increased NSCLC risk was noted (CT/TT vs. CC: adjusted OR, 1.21; 95% CI, 0.97-1.51; P = 0.097). In the meta-analysis, we found a significant association between PPARG c.1347C>T polymorphism and overall cancer risk (T vs. C: OR, 1.13; 95% CI, 1.03-1.23; P = 0.006; TT vs. CC: OR, 1.29; 95% CI, 1.07-1.56; P = 0.008, CT/TT vs. CC: OR, 1.11; 95% CI, 1.02-1.21; P = 0.014 and TT vs.

Ct/cc: OR, 1.26; 95% CI, 1.04-1.52; P = 0.016). In a subgroup analysis by ethnicity, evidence of significant association between PPARG c.1347C>T polymorphism and cancer risk was found among Asians and mixed populations. In a subgroup analysis by cancer type, PPARG c.1347C>T polymorphism was associated with risk of esophageal cancer and glioblastoma. In addition, in a subgroup analysis by origin of cancer cell, evidence of significant association between PPARG c.1347C>T polymorphism and cancer risk was also found among epithelial tumor. In conclusion, the findings indicate PPARG c.1347C>T polymorphism may increase the susceptibility of cancer.

Keywords: PPARG; non-small cell lung cancer; polymorphism; risk.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors have no potential financial conflicts of interest.

Figures

Figure 1
Figure 1. Flow diagram of the meta–analysis of the association between PPARG c.1347C>T polymorphism and cancer risk
Figure 2
Figure 2. Meta-analysis of the association between PPARG c.1347C>T polymorphism and cancer risk (TT/CT vs. CC
random–effects model).
Figure 3
Figure 3. Begg's funnel plot of meta–analysis of the association between PPARG c.1347C>T polymorphism and cancer risk (TT/CT vs. CC compare genetic model, random–effects model)
Figure 4
Figure 4. Sensitivity analysis of the influence of TT/CT vs. CC comparison (random–effects estimates for PPARG c.1347C > T polymorphism)
See this image and copyright information in PMC

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