Cell sheets in cell therapies

Giles T S Kirby¹, Andrew Michelmore², Louise E Smith³, Jason D Whittle², Robert D Short⁴

Affiliations

¹ Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia. Electronic address: giles.kirby@unisa.edu.au.
² Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia; School of Engineering, University of South Australia, Mawson Lakes, Adelaide, Australia.
³ Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia.
⁴ Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia; Materials Science Institute and Department of Chemistry, University of Lancaster, City of Lancaster, United Kingdom.

PMID: 29254764
DOI: 10.1016/j.jcyt.2017.11.004

Review

Cell sheets in cell therapies

Giles T S Kirby et al. Cytotherapy. 2018 Feb.

. 2018 Feb;20(2):169-180.

doi: 10.1016/j.jcyt.2017.11.004. Epub 2017 Dec 15.

Authors

Giles T S Kirby¹, Andrew Michelmore², Louise E Smith³, Jason D Whittle², Robert D Short⁴

Affiliations

¹ Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia. Electronic address: giles.kirby@unisa.edu.au.
² Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia; School of Engineering, University of South Australia, Mawson Lakes, Adelaide, Australia.
³ Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia.
⁴ Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia; Materials Science Institute and Department of Chemistry, University of Lancaster, City of Lancaster, United Kingdom.

PMID: 29254764
DOI: 10.1016/j.jcyt.2017.11.004

Abstract

This review aims to provide a broad introduction to the use of cell sheets and the role of materials in the delivery of cell sheets to patients within a clinical setting. Traditionally, cells sheets have been, and currently are, fabricated using established and accepted cell culture methods within standard formats (e.g., petri dishes) utilizing biological substrates. Synthetic surfaces provide a far more versatile system for culturing and delivering cell sheets. This has the potential to positively affect quality, and efficient, localized cell delivery has a significant impact on patient outcome and on the overall cost of goods. We highlight current applications of these advanced carriers and future applications of these surfaces and cell sheets with an emphasis both on clinical use and regulatory requirements.

Keywords: culture; plasma polymerization; regeneration; sheet; therapy.

PubMed Disclaimer

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Cell sheets in cell therapies

Affiliations

Cell sheets in cell therapies

Authors

Affiliations

Abstract

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources