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. 2010 Feb 16:9:39-45.
eCollection 2010.

Changes in haematological indices and protein concentrations in Trypanosoma brucei infected rats treated with homidium chloride and diminazene aceturate

Faoziyat Adenike Sulaiman  1 , Oluyomi Stephen Adeyemi  2
Affiliations

Changes in haematological indices and protein concentrations in Trypanosoma brucei infected rats treated with homidium chloride and diminazene aceturate

Faoziyat Adenike Sulaiman et al. EXCLI J. .

Abstract

Anaemia and immunosuppresion have been shown to be a cardinal feature in African trypanosomosis. In this study, we have evaluated and compared the capacity of two registered veterinary trypanocides Novidium® (homidium chloride) and Berenil® (diminazene aceturate) to reduce haematological and biochemical lesions in rats experimentally infected with T. brucei. Packed cell volume (PCV), lymphocyte and eosinophil values in infected negative control group were significantly different and lower compared to positive control group as well as infected animals treated with homidium chloride and diminazene aceturate (P<0.05). Also the white blood cell (WBC) and neutrophil counts in the negative control group were lower and significantly different from the other groups indicating evidence of infection-induced immunosuppresion. Haematological indices in infected rats treated with homidium chloride and diminazene aceturate were higher (P<0.05) than obtained in infected negative control group and significantly different from positive control (P<0.05). Total protein and albumin concentrations in infected negative control group were higher and significantly different from control and treated animals (P<0.05). In contrast, significantly lower values were obtained for albumin concentrations in treated animals compared to both negative and positive control groups (P<0.05). Results suggest that drugs administered have capacity to improved blood components as well as reverse immunosuppressive action of infecting trypanosomes.

Keywords: T. brucei; anaemia; biochemical lesions; immunosuppression; trypanocides.

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Figures

Table 1
Table 1. Effects of daily administration of homidium chloride (novidium®) and diminazene aceturate (berenil®) on haematological indices in rat serum
Table 2
Table 2. Effects of daily administration of novidium® and berenil® on protein concentration in rat serum and tissues
Table 3
Table 3. Effects of daily administration of novidium® and berenil® on albumin concentration in rat serum and tissues
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References

    1. Abubakar A, Iliyasu B, Yusuf AB, Igweh AC, Onyekwelu NA, Shamaki BA, Afolayan DO, Ogbadoyi EO. Antitrypanosomal and haematological effects of selected Nigerian medicinal plants in Wistar rats. Biokemistri. 2005;17:95–99.
    1. Adamu S, Barde N, Abenga JN, Useh NM, Ibrahim NDG, Esievo KAN. Experimental Trypanosoma brucei infection-induced changes in the serum profiles of lipids and cholesterol and the clinical implications in pigs. J Cell Animal Biol. 2009;3(2):15–20.
    1. Adeyemi OS, Akanji MA, Oguntoye S. Ethanolic leaf extract of Psidium guajava: Phytochemical and trypanocidal activity in rats infected with Trypanosoma brucei brucei. J Medicinal Plants Res. 2009;3:420–423.
    1. Akanji MA, Adeyemi OS, Oguntoye SO, Sulyman F. Psidium guajava extract reduces trypanosomosis associated lipid peroxidation and raises glutathione concentrations in infected animals. EXCLI J. 2009;8:148–154.
    1. Anosa VO. Haematological and biochemical changes in human and animal trypanosomiasis. Part I. Rev Elev Med Vet Pays Trop. 1988;41:65–78. - PubMed

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