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. 2017 Nov 3;4(4):ofx239.
doi: 10.1093/ofid/ofx239. eCollection 2017 Fall.

Weight Gain: A Possible Side Effect of All Antiretrovirals

Lucia Taramasso  1 , Elena Ricci  2 , Barbara Menzaghi  3 , Giancarlo Orofino  4 , Simone Passerini  5 , Giordano Madeddu  6 , Canio Vito Martinelli  7 , Giuseppe Vittorio De Socio  8 , Nicola Squillace  9 , Stefano Rusconi  10 , Paolo Bonfanti  11 , Antonio Di Biagio  12 ; CISAI Study Group
Collaborators, Affiliations

Weight Gain: A Possible Side Effect of All Antiretrovirals

Lucia Taramasso et al. Open Forum Infect Dis. .

Abstract

Weight gain and body mass index (BMI) increase are central issues in patients living with HIV who need to minimize the risk of metabolic disease. Information collected through the SCOLTA cohort revealed significant 1-year BMI increase in patients treated with dolutegravir (P = .004), raltegravir (P = .0004), elvitegravir (P = .004), darunavir (P = .0006), and rilpivirine (P = .029). BMI gain correlated with low baseline BMI (P = .002) and older age (P = .0007) in Centers for Disease Control and Prevention stages A/B, with lower BMI (P = .005) and CD4+ T-cell count (P = .007) at enrollment in stage C.

Keywords: ART; BMI; INSTI; cardiovascular risk; darunavir; rilpivirine; weight.

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