Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan;144(1):99-107.
doi: 10.1007/s00432-017-2560-x. Epub 2017 Dec 18.

Cardiovascular effects of Hodgkin's lymphoma: a review of literature

Aasems Jacob  1 , Bragadheeswar Thyagarajan  2 , Monisha Priyadarshini Kumar  3 , Nasreen Shaikh  4 , David Sharon  4
Affiliations

Cardiovascular effects of Hodgkin's lymphoma: a review of literature

Aasems Jacob et al. J Cancer Res Clin Oncol. 2018 Jan.

Abstract

Hodgkin's lymphoma (HL) constitutes 0.6% of all the cancers diagnosed worldwide and 10% of all lymphomas. Ten-year survival rate for HL is estimated to be 80% and cardiovascular death is the prevalent cause for a non-malignant death among these HL survivors. We are reviewing the cardiovascular morbidities associated with Hodgkin's lymphoma from the available literature. We performed a systematic review of all articles published from January 1, 1960 to October 1, 2016 on the MEDLINE database using PubMed search engine. Key factors in the diagnosis and management of these conditions are discussed in individual sections.

Keywords: Cancer; Cardiac; Cardiology; Cardiovascular; Chemotherapy; Complications; Hodgkin’s lymphoma; Lymphoma; Malignancy; Radiation; Treatment.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
EKG showing electrical alternans in a 48-year-old patient with Hodgkin’s lymphoma treated with chemoradiation, who developed pericardial tamponade
Fig. 2
Fig. 2
2D echocardiogram image of the same patient showing massive pericardial effusion which caused tamponade
See this image and copyright information in PMC

References

    1. Adams MJ, Lipsitz SR, Colan SD et al (2004) Cardiovascular status in long-term survivors of Hodgkin’s disease treated with chest radiotherapy. J Clin Oncol 22:3139 - DOI - PubMed
    1. Adler Y, Charron P, Imazio M et al (2015) European Society of Cardiology (ESC) 2015 ESC guidelines for the diagnosis and management of pericardial diseases: the task force for the diagnosis and management of pericardial diseases of the European Society of Cardiology (ESC) endorsed by: the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 36(42):2921–2964 - DOI - PMC - PubMed
    1. Akhter MW, Aronson D, Bitar F, Khan S, Singh H et al (2004) Effect of elevated admission serum creatinine and its worsening on outcome in hospitalised patients with decompensated heart failure. Am J Cardiol 94:957–960 - DOI - PubMed
    1. Aleman BM, van den Belt-Dusebout AW, Klokman WJ et al (2003) Long-term cause-specific mortality of patients treated for Hodgkin’s disease. J Clin Oncol 21:3431–3439 - DOI - PubMed
    1. Aleman BM, van den Belt-Dusebout AW, De Bruin ML et al (2007) Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood 109(5):1878–1886 - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources