Probing Cilia-Associated Signaling Proteomes in Animal Evolution

Avital S Shulman¹, Meng-Fu Bryan Tsou²

Affiliations

¹ Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
² Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: tsoum@mskcc.org.

PMID: 29257946
DOI: 10.1016/j.devcel.2017.12.009

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Probing Cilia-Associated Signaling Proteomes in Animal Evolution

Avital S Shulman et al. Dev Cell. 2017.

Free article

. 2017 Dec 18;43(6):653-655.

doi: 10.1016/j.devcel.2017.12.009.

Authors

Avital S Shulman¹, Meng-Fu Bryan Tsou²

Affiliations

¹ Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
² Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: tsoum@mskcc.org.

PMID: 29257946
DOI: 10.1016/j.devcel.2017.12.009

Abstract

Cilia have evolved to function as essential sensory organelles in animals. To understand why cilia are intimately associated with cell signaling, Sigg et al. (2017) develop and apply a comparative proteomics approach, reported in this issue of Developmental Cell, to analyze the evolutionary relationship between cilia and various signaling pathways.

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Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.
Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G 3rd, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF. Sigg MA, et al. Dev Cell. 2017 Dec 18;43(6):744-762.e11. doi: 10.1016/j.devcel.2017.11.014. Dev Cell. 2017. PMID: 29257953 Free PMC article.

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Probing Cilia-Associated Signaling Proteomes in Animal Evolution

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Probing Cilia-Associated Signaling Proteomes in Animal Evolution

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