Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec 16;18(12):2714.
doi: 10.3390/ijms18122714.

Mussel-Inspired Fabrication of Konjac Glucomannan/Poly (Lactic Acid) Cryogels with Enhanced Thermal and Mechanical Properties

Lin Wang  1 , Yi Yuan  2 , Ruo-Jun Mu  3 , Jingni Gong  4 , Yongsheng Ni  5 , Xin Hong  6 , Jie Pang  7 , Chunhua Wu  8
Affiliations

Mussel-Inspired Fabrication of Konjac Glucomannan/Poly (Lactic Acid) Cryogels with Enhanced Thermal and Mechanical Properties

Lin Wang et al. Int J Mol Sci. .

Abstract

Three-dimensional nanofibers cryogels (NFCs) with both thermally-tolerant and mechanically-robust properties have potential for wide application in biomedical or food areas; however, creating such NFCs has proven to be extremely challenging. In this study, konjac glucomannan (KGM)/poly (lactic acid) (PLA)-based novel NFCs were prepared by the incorporation of the mussel-inspired protein polydopamine (PDA) via a facile and environmentally-friendly electrospinning and freeze-shaping technique. The obtained KGM/PLA/PDA (KPP) NFCs were characterized by field emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and compressive and tensile test. The results showed that the hierarchical cellular structure and physicochemical properties of KPP NFCs were dependent on the incorporation of PDA content. Moreover, the strong intermolecular hydrogen bond interactions among KGM, PLA and PDA also gave KPP NFCs high thermostability and mechanically-robust properties. Thus, this study developed a simple approach to fabricate multifunctional NFCs with significant potential for biomedical or food application.

Keywords: konjac glucomannan; mechanical properties; nanofibers cryogels; poly (lactic acid); polydopamine.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
The mechanism diagram and hydrogen-bond interaction (red dotted circle) of KGM/PLA nanofibers and PDA.
Figure 1
Figure 1
The morphology image of the electrospun KGM nanofibers (a,b) and KGM/PLA nanofibers (c,d).
Figure 2
Figure 2
The images of (a) KPPA0; (b) KPPA2 and (c) KPPA4 cryogels.
Figure 3
Figure 3
The image of KPP NFCs and the FESEM images of (a) KPPA0; (b) KPPA1; (c) KPPA2; (d) KPPA3; (e) KPPA4; (f–h) fibers of KPPA4 and (i) the pore structure of KPPA4.
Figure 4
Figure 4
FTIR spectra of the KPPA0, KPPA1, KPPA2, KPPA3 and KPPA4 cryogels.
Figure 5
Figure 5
X-ray diffraction patterns of the KPPA0, KPPA1, KPPA2, KPPA3 and KPPA4 cryogels.
Figure 6
Figure 6
TGA curves of the KPPA0, KPPA1, KPPA2, KPPA3 and KPPA4 cryogels.
Figure 7
Figure 7
The DSC curve of the KPPA0, KPPA1, KPPA2, KPPA3 and KPPA4 cryogels.
Figure 8
Figure 8
Compressive stress of the KPPA0, KPPA1, KPPA2, KPPA3 and KPPA4 cryogels.
Figure 9
Figure 9
Tensile stress of the KPPA0, KPPA1, KPPA2, KPPA3 and KPPA4 cryogels.
Figure 10
Figure 10
Synthesis scheme of biodegradable nanofiber-assembled NFCs based on konjac glucomannan (KGM)/polydopamine (PDA)/poly (lactic acid).
See this image and copyright information in PMC

References

    1. Henderson T.M.A., Ladewig K., Haylock D.N., Mclean K.M., O’Connor A.J. Cryogels for biomedical applications. J. Mater. Chem. B. 2013;1:2682–2695. doi: 10.1039/c3tb20280a. - DOI - PubMed
    1. Konovalova M.V., Markov P.A., Durnev E.A., Kurek D.V., Popov S.V., Varlamov V.P. Preparation and biocompatibility evaluation of pectin and chitosan cryogels for biomedical application. J. Biomed. Mater. Res. A. 2017;105:547–556. doi: 10.1002/jbm.a.35936. - DOI - PubMed
    1. Wan W., Bannerman A.D., Yang L., Mak H. Poly (Vinyl Alcohol) cryogels for biomedical applications. Adv. Polym. Sci. 2014;263:283–321.
    1. Wang X., Min B.G. Cadmium sorption properties of poly (vinyl alcohol)/hydroxyapatite cryogels: I. kinetic and isotherm studies. J. Sol-Gel Sci. Technol. 2007;43:99–104. doi: 10.1007/s10971-007-1548-4. - DOI
    1. Erdem A., Ngwabebhoh F.A., Çetintaş S., Bingöl D., Yildiz U. Fabrication and characterization of novel macroporous jeffamine/diamino hexane cryogels for enhanced Cu(II) metal uptake: Optimization, isotherms, kinetics and thermodynamic studies. Chem. Eng. Res. Des. 2016;117:122–138. doi: 10.1016/j.cherd.2016.10.010. - DOI

LinkOut - more resources