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. 2016 Dec 26;16(1):40-44.
doi: 10.1002/rmb2.12004. eCollection 2017 Jan.

Analyzing the risk factors for a diminished oocyte retrieval rate under controlled ovarian stimulation

Mayumi Nakamura  1 , Yoshiki Yamashita  1   2 , Atsushi Hayashi  1 , Natsuho Saito  1 , Masae Yu  1 , Masami Hayashi  1 , Yoshito Terai  1 , Masahide Ohmichi  1
Affiliations

Analyzing the risk factors for a diminished oocyte retrieval rate under controlled ovarian stimulation

Mayumi Nakamura et al. Reprod Med Biol. .

Abstract

Aim: To investigate which risk factors contribute to a lower oocyte retrieval ratio in women who are receiving controlled ovarian hyperstimulation.

Methods: The authors retrospectively analyzed 329 in vitro fertilization (IVF) cycles under controlled ovarian hyperstimulation by using a gonadotropin-releasing hormone antagonist or agonist at Osaka Medical College, Japan. The patients were classified into five groups: advanced age, male infertility, severe endometriosis, tubal infertility, and unexplained infertility. The primary outcomes were the patients' age, oocyte retrieval ratio, serum basal follicle-stimulating hormone, total dose of gonadotropin, and the clinical outcome. A secondary outcome was the stepwise multivariate logistic regression analysis to assess the factors associated with the failure of oocyte retrieval.

Results: The oocyte retrieval ratio declined significantly with the patient's age. The ratio of endometriosis in unsuccessful cases was significantly higher than that in successful cycles. Advanced age and endometriosis were the factors that were significantly associated with a lowered oocyte retrieval rate.

Conclusion: Advanced age and endometriosis are high-risk factors that contribute to oocyte retrieval failure in infertile patients who are receiving IVF treatment.

Keywords: advanced age; controlled ovarian hyperstimulation; endometriosis; oocyte retrieval ratio; unexplained infertility.

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Figures

Figure 1
Figure 1
Relationship between the oocyte retrieval ratio and the patient's age
Figure 2
Figure 2
The oocyte retrieval ratio (%) in cases where at least one high‐quality embryo was retrieved was statistically higher than that in cases where a high‐quality embryo was not available
Figure 3
Figure 3
Forest plot (univariate/multivariate logistic regression) indicating the association between the cause of infertility and the risk of oocyte retrieval failure among 329 treatment cycles. CI, confidence interval
See this image and copyright information in PMC

References

    1. Surrey ES, Schoolcraft WB. Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques. Fertil Steril. 2000;73:667–676. - PubMed
    1. Hellberg D, Waldenström U, Nilsson S. Defining a poor responder in in vitro fertilization. Fertil Steril. 2004;82:488–490. - PubMed
    1. Yamashita Y, Ueda M, Takehara M, Terai Y, Hang YC, Ueki M. Influence of severe endometriosis on gene expression of vascular endothelial growth factor and interleukin‐6 in granulosa cells under controlled ovarian stimulation for IVF–ET. Fertil Steril. 2002;78:865–871. - PubMed
    1. Menken J, Trussell J, Larsen U. Age and infertility. Science. 1986;233:1389–1394. - PubMed
    1. Baird DT, Collins J, Egozcue J, et al. Hum Reprod Update. 2005;11:261–276. - PubMed

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