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Review
. 2016 Apr 25:36:2.
doi: 10.1186/s41232-016-0004-7. eCollection 2016.

Retinal regeneration by transplantation of retinal tissue derived from human embryonic or induced pluripotent stem cells

Hiroshi Shirai  1   2 , Michiko Mandai  1
Affiliations
Review

Retinal regeneration by transplantation of retinal tissue derived from human embryonic or induced pluripotent stem cells

Hiroshi Shirai et al. Inflamm Regen. .

Abstract

Rodent studies have recently demonstrated substantial integration of transplanted photoreceptors, with potential synaptic connection and functional restoration. Consequently, photoreceptor transplantation therapy for retinitis pigmentosa is attracting a growing interest in the field of translational research. Differentiation strategies for the formation of three-dimensional (3D) retinal tissue that are suitable for graft preparation have also been introduced via the use of human embryonic stem cells (hESCs) and human induced pluripotent stem cells. We have recently shown that hESC-derived retinal tissue (hESC-retina) can survive, mature, and potentially integrate with host secondary neurons following transplantation into two established primate models of retinal degeneration. Our data demonstrated the feasibility of deploying hESC-retina transplantation as a new remedy with which to restore the vision of patients with end-stage retinal degenerative diseases. In the present mini-review, we provide a short introduction of photoreceptor transplantation research.

Keywords: Photoreceptors; Regeneration; Retina; Transplantation.

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Figures

Fig. 1
Fig. 1
Schematic image of the human eye and therapeutic scheme of retinal transplantation. a Anatomical structure of the human eye and retina, which has three layers of neurons. Photoreceptor cells respond to light and are composed of rods and cones, which contain inner segments (ISs) and outer segments (OSs). b Retinal transplantation scheme. Retinitis pigmentosa (RP) is a group of diseases that cause progressive photoreceptor degeneration. It is hoped that retinal tissue differentiated from human ES/iPS cells could be transplanted into RP patients with a degenerative retina without photoreceptors. Although a transplanted retina contains more or less of INL components, the structured layers of photoreceptors will be in direct contact with the INL of the host retina where graft INLs had been stripped off from graft ONLs
See this image and copyright information in PMC

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