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Review
. 2017 Jul 3:37:16.
doi: 10.1186/s41232-017-0045-6. eCollection 2017.

Clinical trials using mesenchymal stem cells in liver diseases and inflammatory bowel diseases

Atsunori Tsuchiya  1 , Yuichi Kojima  1 , Shunzo Ikarashi  1 , Satoshi Seino  1 , Yusuke Watanabe  1 , Yuzo Kawata  1 , Shuji Terai  1
Affiliations
Review

Clinical trials using mesenchymal stem cells in liver diseases and inflammatory bowel diseases

Atsunori Tsuchiya et al. Inflamm Regen. .

Abstract

Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functions, suggesting their potential applications in a variety of diseases, including liver disease and inflammatory bowel disease. MSCs help prepare the microenvironment, in response to inflammatory cytokines, by producing immunoregulatory factors that modulate the progression of inflammation by affecting dendritic cells, B cells, T cells, and macrophages. MSCs also produce a large amount of cytokines, chemokines, and growth factors, including exosomes that stimulate angiogenesis, prevent apoptosis, block oxidation reactions, promote remodeling of the extracellular matrix, and induce differentiation of tissue stem cells. According to ClinicalTrials.gov, more than 680 clinical trials using MSCs are registered for cell therapy of many fields including liver diseases (more than 40 trials) and inflammatory bowel diseases (more than 20 trials). In this report, we introduce background and clinical studies of MSCs in liver disease and inflammatory bowel diseases.

Keywords: Cell therapy; Inflammatory bowel disease; Liver disease; Mesenchymal stem cell.

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Figures

Fig. 1
Fig. 1
Summary of clinical trials in liver diseases
Fig. 2
Fig. 2
Summary of clinical trials in inflammatory bowel diseases
See this image and copyright information in PMC

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