Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Dec 7:6:2110.
doi: 10.12688/f1000research.11471.1. eCollection 2017.

Recent advances in the management of non-small cell lung cancer

Samira Shojaee  1 , Patrick Nana-Sinkam  1
Affiliations
Review

Recent advances in the management of non-small cell lung cancer

Samira Shojaee et al. F1000Res. .

Abstract

Lung cancer is the number one cause of cancer-related death in both men and women. However, over the last few years, we have witnessed improved outcomes that are largely attributable to early detection, increased efforts in tobacco control, improved surgical approaches, and the development of novel targeted therapies. Currently, there are several novel therapies in clinical practice, including those targeting actionable mutations and more recently immunotherapeutic agents. Immunotherapy represents the most significant step forward in eradicating this deadly disease. Given the ever-changing landscape of lung cancer management, here we present an overview of the most recent advances in the management of non-small cell lung cancer.

Keywords: ALK mutation; EGFR; Non-Small Cell Lung Cancer.

PubMed Disclaimer

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

References

    1. Downward J: Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 2003;3(1):11–22. 10.1038/nrc969 - DOI - PubMed
    1. Prenzel N, Fischer OM, Streit S, et al. : The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer. 2001;8(1):11–31. 10.1677/erc.0.0080011 - DOI - PubMed
    1. Davies H, Bignell GR, Cox C, et al. : Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949–54. 10.1038/nature00766 - DOI - PubMed

    2. F1000 Recommendation

    1. Tzahar E, Waterman H, Chen X, et al. : A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol. 1996;16(10):5276–87. 10.1128/MCB.16.10.5276 - DOI - PMC - PubMed
    1. Sadiq AA, Salgia R: MET as a possible target for non-small-cell lung cancer. J Clin Oncol. 2013;31(8):1089–96. 10.1200/JCO.2012.43.9422 - DOI - PMC - PubMed