Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Dec 5:5:103.
doi: 10.3389/fcell.2017.00103. eCollection 2017.

Potential Use of Human Periapical Cyst-Mesenchymal Stem Cells (hPCy-MSCs) as a Novel Stem Cell Source for Regenerative Medicine Applications

Marco Tatullo  1 , Bruna Codispoti  1 , Andrea Pacifici  2 , Francesca Palmieri  1 , Massimo Marrelli  1 , Luciano Pacifici  2 , Francesco Paduano  1
Affiliations
Review

Potential Use of Human Periapical Cyst-Mesenchymal Stem Cells (hPCy-MSCs) as a Novel Stem Cell Source for Regenerative Medicine Applications

Marco Tatullo et al. Front Cell Dev Biol. .

Abstract

Mesenchymal stem cells (MSCs) are attracting growing interest by the scientific community due to their huge regenerative potential. Thus, the plasticity of MSCs strongly suggests the utilization of these cells for regenerative medicine applications. The main issue about the clinical use of MSCs is related to the complex way to obtain them from healthy tissues; this topic has encouraged scientists to search for novel and more advantageous sources of these cells in easily accessible tissues. The oral cavity hosts several cell populations expressing mesenchymal stem cell like-features, furthermore, the access to oral and dental tissues is simple and isolation of cells is very efficient. Thus, oral-derived stem cells are highly attractive for clinical purposes. In this context, human periapical cyst mesenchymal stem cells (hPCy-MSCs) exhibit characteristics similar to other dental-derived MSCs, including their extensive proliferative potential, cell surface marker profile and the ability to differentiate into various cell types such as osteoblasts, adipocytes and neurons. Importantly, hPCy-MSCs are easily collected from the surgically removed periapical cysts; this reusing of biological waste guarantees a smart source of stem cells without any impact on the surrounding healthy tissues. In this review, we report the most interesting research topics related to hPCy-MSCs with a newsworthy discussion about the future insights. This newly discovered cell population exhibits interesting and valuable potentialities that could be of high impact in the future regenerative medicine applications.

Keywords: cell therapy; human periapical cyst mesenchymal stem cells (hPCy-MSCs); mesenchymal stem cells (MSCs); regenerative medicine; waste medicine.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mesenchymal stem cells isolated from oral tissues. Chronologic flow. DPSCs, dental pulp stem cells; SHEDs, stem cells from human exfoliated deciduous teeth; PDLSCs, periodontal ligament stem cells; SCAPs, stem cells from apical papilla; hPCy-MSCs, human periapical cyst-mesenchymal stem cells.
Figure 2
Figure 2
Clinical potentialities of hPCy-MSCs.
See this image and copyright information in PMC

References

    1. Barry F. P., Murphy J. M. (2004). Mesenchymal stem cells: clinical applications and biological characterization. Int. J. Biochem. Cell Biol. 36, 568–584. 10.1016/j.biocel.2003.11.001 - DOI - PubMed
    1. Beyer Nardi N., da Silva Meirelles L. (2006). Mesenchymal stem cells: isolation, in vitro expansion and characterization. Handb. Exp. Pharmacol. 174, 249–282. 10.1007/3-540-31265-X_11 - DOI - PubMed
    1. Catacchio I., Berardi S., Reale A., De Luisi A., Racanelli V., Vacca A., et al. . (2013). Evidence for bone marrow adult stem cell plasticity: properties, molecular mechanisms, negative aspects, and clinical applications of hematopoietic and mesenchymal stem cells transdifferentiation. Stem Cells Int. 2013:589139. 10.1155/2013/589139 - DOI - PMC - PubMed
    1. Cavalcanti B. N., Zeitlin B. D., Nör J. E. (2013). A hydrogel scaffold that maintains viability and supports differentiation of dental pulp stem cells. Dent. Mater. 29, 97–102. 10.1016/j.dental.2012.08.002 - DOI - PMC - PubMed
    1. Chamberlain G., Fox J., Ashton B., Middleton J. (2007). Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25, 2739–2749. 10.1634/stemcells.2007-0197 - DOI - PubMed

LinkOut - more resources