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Case Reports
. 2016 Aug 20:6:1-3.
doi: 10.1016/j.ensci.2016.08.002. eCollection 2017 Mar.

Prosopometamorphopsia and alexia following left splenial corpus callosum infarction: Case report and literature review

Connor W McCarty  1   2 , Gabriel M Gordon  2 , Aimee Walker  2 , Philip Delio  3 , Robert A Kolarczyk  4 , Dante J Pieramici  2
Affiliations
Case Reports

Prosopometamorphopsia and alexia following left splenial corpus callosum infarction: Case report and literature review

Connor W McCarty et al. eNeurologicalSci. .

Abstract

Background: Lesions to the posterior section of the corpus callosum, called the splenium, and the immediate area have been separately associated with perceived visual distortions of the face (prosopometamorphopsia) or difficulty reading (alexia).

Case report: This case report describes a right-handed patient who complained of prosopometamorphopsia associated with the lower part of the face and alexia following infarction of the left splenium in the corpus callosum.

Conclusions: The splenium and adjacent retrosplenial cortex facilitate the transfer of visual information and memory function between the two hemispheres of the brain and along the Papez circuit, respectively. We believe that damage to this singular area of the brain could bring about several concurrent yet disparate symptoms, such as the reported prosopometamorphopsia and alexia with this patient.

Keywords: Alexia; Prosopometamorphopsia; Retrosplenial cortex; Splenium; Transient global amnesia.

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Figures

Fig. 1
Fig. 1
A: MRI of the brain showing infarct within the left splenium. B: MRI of the orbits showing tortuosity of the optic nerves. C: MRI of the brain showing a partially-empty sella.
See this image and copyright information in PMC

References

    1. Ay H. Diffusion-weighted MRI characterizes the ischemic lesion in transient global amnesia. Neurology. 1998;51:901–903. - PubMed
    1. Bala A. Visual disorders, the prosopometamorphopsia and prosopagnosia type in the early days after the onset of brain hemorrhagic stroke – a case report. Neurocase. 2015;21(3):331–338. - PubMed
    1. Cha S.Y., Kang T.H., Kim S.J. Selective anterograde amnesia associated with hippocampal and splenial damage after heat stroke. Clin. Neurol. Neurosurg. 2013;115:1867–1870. - PubMed
    1. Cho J.Y., Moon S.Y., Hong K.S. Teaching NeuroImages: unilateral prosopometamorphopsia as a dominant hemisphere-specific disconnection sign. Neurology. 2011;76(22):e110. - PubMed
    1. Damasio A.R., Damasio H. The anatomic basis of pure alexia. Neurology. 1983:1573–1583. - PubMed

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