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Case Reports
. 2017 Sep 1:8:11-13.
doi: 10.1016/j.ajoc.2017.08.001. eCollection 2017 Dec.

Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy

Francisco J Irizarry  1 , Laura J Kopplin  2 , Sherveen S Salek  3 , Grazyna Adamus  2 , Mohamed Saleh  2 , Kristin Biggee  2 , Phoebe Lin  2 , James T Rosenbaum  2   4
Affiliations
Case Reports

Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy

Francisco J Irizarry et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: To report novel optical coherence tomography findings in a case of anti-α-enolase cancer associated retinopathy.

Observations: An elderly female presented with bilateral decreased vision and a recent diagnosis of ovarian carcinoma. Optical coherence tomography demonstrated bilateral loss of outer retinal structures and macular edema. Serum testing found antibodies against α-enolase and 82-84 kDa proteins. Outer retinal structures showed recovery, macular edema resolved and repeat anti-retinal antibody testing became negative following cancer therapy and topical difluprednate treatment.

Conclusions and importance: Cancer associated retinopathy is a paraneoplastic disease that results in damage to retinal structures through an autoimmune response. The damage is generally considered to be irreversible; however, in rare cases, such as observed here, retinal structures may demonstrate recovery after treatment.

Keywords: Cancer associated retinopathy; Optical coherence tomography.

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Figures

Fig. 1
Fig. 1
OCT images of initial loss and final improvement of the ISOS junction. Loss of ISOS hyperreflectivity (white arrows) and concurrent CME at time of initial vision loss OD (A) and OS (B). Persistence of ISOS loss and CME after 1 month of observation OD (C) and OS (D). E: Partial recovery of ISOS hyperreflectivity (white arrows) with residual foveal outer retinal nodularity OD one year after initial findings. F: Recovery of ISOS hyperreflectivity (white arrows) with mild residual foveal disruption one year after initial findings. OCT = optical coherence tomography, ISOS = inner segment/outer segment, CME = cystoid macular edema.
See this image and copyright information in PMC

References

    1. Rahimy E., Sarraf D. Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: evaluation and management. Surv Ophthalmol. 2013;58(5):430–458. - PubMed
    1. Weleber R.G., Watzke R.C., Shults W.T. Clinical and electrophysiologic characterization of paraneoplastic and autoimmune retinopathies associated with anti-enolase antibodies. Am J Ophthalmol. 2005;139(5):780–794. - PubMed
    1. Magrys A., Anekonda T., Ren G., Adamus G. The role of anti-alpha-enolase autoantibodies in pathogenicity of autoimmune-mediated retinopathy. J Clin Immunol. 2007;27(2):181–192. - PubMed
    1. Adamus G., Choi D., Raghunath A., Schiffman J. Significance of anti-retinal autoantibodies in cancer-associated retinopathy with gynecological cancers. J Clin Exp Ophthalmol. 2013;4(6):307. - PMC - PubMed
    1. Abazari A., Allam S.S., Adamus G., Ghazi N.G. Optical coherence tomography findings in autoimmune retinopathy. Am J Ophthalmol. 2012;153(4):750–756. - PMC - PubMed

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