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Meta-Analysis
. 2017 Dec 20;12(12):CD010470.
doi: 10.1002/14651858.CD010470.pub3.

Interventions for managing taste disturbances

Sumanth Kumbargere Nagraj  1 , Renjith P George, Naresh Shetty, David Levenson, Debra M Ferraiolo, Ashish Shrestha
Affiliations
Meta-Analysis

Interventions for managing taste disturbances

Sumanth Kumbargere Nagraj et al. Cochrane Database Syst Rev. .

Abstract

Background: The sense of taste is very much essential to the overall health of an individual. It is a necessary component to enjoy one's food, which in turn provides nutrition to an individual. Any disturbance in taste perception can hamper quality of life in such patients by influencing their appetite, body weight and psychological well-being. Taste disorders have been treated using different modalities of treatment and there is no consensus for the best intervention. Hence this Cochrane Review was undertaken. This is an update of the Cochrane Review first published in November 2014.

Objectives: To assess the effects of interventions for the management of patients with taste disturbances.

Search methods: Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 4 July 2017); the Cochrane Central Register of Controlled Trials (CENTRAL; 2017 Issue 6) in the Cochrane Library (searched 4 July 2017); MEDLINE Ovid (1946 to 4 July 2017); Embase Ovid (1980 to 4 July 2017); CINAHL EBSCO (1937 to 4 July 2017); and AMED Ovid (1985 to 4 July 2017). The US National Institutes of Health Ongoing Trials Register ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization International Clinical Trials Registry Platform were searched for trials. Abstracts from scientific meetings and conferences were searched on 25 September 2017. No restrictions were placed on the language or date of publication when searching the electronic databases.

Selection criteria: We included all randomised controlled trials (RCTs) comparing any pharmacological agent with a control intervention or any non-pharmacological agent with a control intervention. We also included cross-over trials in the review.

Data collection and analysis: Two pairs of review authors independently, and in duplicate, assessed the quality of trials and extracted data. Wherever possible, we contacted trial authors for additional information. We collected adverse events information from the trials.

Main results: We included 10 trials (581 participants), nine of which we were able to include in the quantitative analyses (566 participants). We assessed three trials (30%) as having a low risk of bias, four trials (40%) at high risk of bias and three trials (30%) as having an unclear risk of bias. We only included studies on taste disorders in this review that were either idiopathic, or resulting from zinc deficiency or chronic renal failure.Of these, nine trials with 544 people compared zinc supplements to placebo for patients with taste disorders. The participants in two trials were children and adolescents with respective mean ages of 10 and 11.2 years and the other seven trials had adult participants. Out of these nine, two trials assessed the patient-reported outcome for improvement in taste acuity using zinc supplements (risk ratio (RR) 1.40, 95% confidence interval (CI) 0.94 to 2.09; 119 participants, very low-quality evidence). We meta-analysed for taste acuity improvement using objective outcome (continuous data) in idiopathic and zinc-deficient taste disorder patients (standardised mean difference (SMD) 0.44, 95% CI 0.23 to 0.65; 366 participants, three trials, very low-quality evidence). We also analysed one cross-over trial separately using the first half of the results for taste detection (mean difference (MD) 2.50, 95% CI 0.93 to 4.07; 14 participants, very low-quality evidence), and taste recognition (MD 3.00, 95% CI 0.66 to 5.34; 14 participants, very low-quality evidence). We meta-analysed taste acuity improvement using objective outcome (dichotomous data) in idiopathic and zinc-deficient taste disorder patients (RR 1.42, 95% 1.09 to 1.84; 292 participants, two trials, very low-quality evidence). Out of the nine trials using zinc supplementation, four reported adverse events like eczema, nausea, abdominal pain, diarrhoea, constipation, decrease in blood iron, increase in blood alkaline phosphatase, and minor increase in blood triglycerides.One trial tested taste discrimination using acupuncture (MD 2.80, 95% CI -1.18 to 6.78; 37 participants, very low-quality evidence). No adverse events were reported in the acupuncture trial.None of the included trials could be included in the meta-analysis for health-related quality of life in taste disorder patients.

Authors' conclusions: We found very low-quality evidence that was insufficient to conclude on the role of zinc supplements to improve taste acuity reported by patients and very low-quality evidence that zinc supplements improve taste acuity in patients with zinc deficiency/idiopathic taste disorders. We did not find any evidence to conclude the role of zinc supplements for improving taste discrimination, or any evidence addressing health-related quality of life due to taste disorders.We found very low-quality evidence that is not sufficient to conclude on the role of acupuncture for improving taste discrimination in cases of idiopathic dysgeusia (distortion of taste) and hypogeusia (reduced ability to taste). We were unable to draw any conclusions regarding the superiority of zinc supplements or acupuncture as none of the trials compared these interventions.

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Conflict of interest statement

Sumanth Kumbargere Nagraj: none known. Renjith P George: none known. Naresh Shetty: none known. David Levenson: none known. Debra M Ferraiolo: none known. Ashish Shrestha: none known.

Figures

1
1
Study flow diagram.
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
3
3
Forest plot of comparison: 1 Zinc versus placebo, outcome: 1.1 Taste acuity improvement ‐ Patient‐reported outcome.
4
4
Forest plot of comparison: 1 Zinc versus placebo, outcome: 1.2 Taste acuity improvement ‐ Objective outcome ‐ Continuous data.
5
5
Forest plot of comparison: 1 Zinc versus placebo, outcome: 1.5 Taste acuity improvement ‐ Objective outcome ‐ Dichotomous.
1.1
1.1. Analysis
Comparison 1 Zinc versus placebo, Outcome 1 Taste acuity improvement ‐ Patient‐reported outcome.
1.2
1.2. Analysis
Comparison 1 Zinc versus placebo, Outcome 2 Taste acuity improvement ‐ Objective outcome ‐ Continuous data.
1.3
1.3. Analysis
Comparison 1 Zinc versus placebo, Outcome 3 Taste acuity improvement for different taste sensations.
1.4
1.4. Analysis
Comparison 1 Zinc versus placebo, Outcome 4 Taste acuity improvement ‐ Cross‐over study.
1.5
1.5. Analysis
Comparison 1 Zinc versus placebo, Outcome 5 Taste acuity improvement ‐ Objective outcome ‐ Dichotomous.
1.6
1.6. Analysis
Comparison 1 Zinc versus placebo, Outcome 6 Adverse events.
2.1
2.1. Analysis
Comparison 2 Acupuncture versus sham control, Outcome 1 Taste discrimination.
See this image and copyright information in PMC

Update of

Comment in

References

References to studies included in this review

Brandt 2008 {published data only}
    1. Brandt H, Hauswald B, Langer H, Gleditsch J, Zahnert T. Efficacy of acupuncture in the treatment of idiopathic taste disorders [Efficacia de la acupuntura para el tratamiento de los trastornos idiopaticos del sentido del gusto]. Revista Internacional de Acupuntura 2008;2:155‐62.
    1. Brandt H, Hauswald B, Langer H, Gleditsch J, Zahnert T. Efficacy of acupuncture in the treatment of idiopathic taste disorders ‐ A randomised placebo‐controlled trial [Wirksamkeit der akupunktur bei der therapievon idiopathischen schmeckstörungen eine randomisierte placebo‐kontrollierte studie]. German Journal of Acupuncture and Related Techniques 2008;51(1):24‐31.
Eggert 1982 {published and unpublished data}
    1. Eggert JV, Siegler RL, Edomkesmalee E. Zinc supplementation in chronic renal failure. International Journal of Pediatric Nephrology 1982;3(1):21‐4. - PubMed
Heckmann 2005 {published data only}
    1. Heckmann SM, Hujoel P, Habiger S, Friess W, Wichmann M, Heckmann JG, et al. Zinc gluconate in the treatment of dysgeusia ‐ a randomised clinical trial. Journal of Dental Research 2005;84(1):35‐8. - PubMed
Ikeda 2013 {published data only}
    1. Ikeda M, Kurono Y, Inokuchi A, Takeda N, Aiba T, Nomura Y, et al. The effect of zinc agent in 219 patients with zinc deficiency‐inductive/idiopathic taste disorder: a placebo controlled randomized study. Nippon Jibiinkoka Gakkai Kaiho (Tokyo) 2013;116:17‐26. - PubMed
Mahajan 1980 {published and unpublished data}
    1. Mahajan SK, Prasad AS, Lambujon J, Abbasi AA, Briggs WA, McDonald FD. Improvement of uraemic hypogeusia by zinc: a double‐blind study. American Journal of Clinical Nutrition 1980;33(7):1517‐21. - PubMed
Mahajan 1982 {published and unpublished data}
    1. Mahajan SK, Prasad AS, Rabbani P, Briggs WA, McDonald FD. Zinc deficiency: a reversible complication of uremia. American Journal of Clinical Nutrition 1982;36(6):1177‐83. - PubMed
Matson 2003 {published data only}
    1. Matson A, Wright M, Oliver A, Woodrow G, King N, Dye L, et al. Zinc supplementation at conventional doses does not improve the disturbance of taste perception in haemodialysis patients. Journal of Renal Nutrition 2003;13(3):224‐8. - PubMed
Sakagami 2009 {published and unpublished data}
    1. Sakagami M, Ikeda M, Tomita H, Ikui A, Aiba T, Takeda N, et al. A zinc‐containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double‐blind, placebo‐controlled, multi‐center study. Acta Oto‐Laryngologica 2009;129(10):1115‐20. - PubMed
Sakai 2002 {published data only}
    1. Sakai F, Yoshida S, Endo S, Tomita H. Double‐blind, placebo‐controlled trial of zinc picolinate for taste disorders. Acta Oto‐Laryngologica. Supplementum 2002;(546):129‐33. - PubMed
    1. Sakai F, Yoshida S, Endo S, Tomita H. Therapeutic efficacy of zinc picolinate in patients with taste disorders. Nihon Jibiinkoka Gakkai Kaiho 1995;98(7):1135‐9. [PUBMED: 7562235] - PubMed
Watson 1983 {published data only}
    1. Watson AR, Stuart A, Wells FE, Houstan IB, Addison GM. Zinc supplementation and its effect on taste acuity in children with chronic renal failure. Human Nutrition. Clinical Nutrition 1983;37(3):219‐25. - PubMed

References to studies excluded from this review

Atkin‐Thor 1978 {published data only}
    1. Atkin‐Thor E, Goddard BW, O'Nion J, Stephen RL, Kolff WJ. Hypogeusia and zinc depletion in chronic dialysis patients. American Journal of Clinical Nutrition 1978;31(10):1948‐51. - PubMed
Brisbois 2011 {published data only}
    1. Brisbois TD, Kock IH, Watanabe SM, Mirhosseini M, Lamoureux DC, Chasen M, et al. Delta‐9‐tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double‐blind, placebo‐controlled pilot trial. Annals of Oncology 2011;22(9):2086‐93. - PubMed
Dahl 1984 {published data only}
    1. Dahl H, Norskov K, Peitersen E, Hilden J. Zinc therapy of acetazolamide‐induced side‐effects. Acta Ophthalmologica 1984;62(5):739‐45. - PubMed
Deniz 2016 {published data only}
    1. Deniz F, Ay SA, Salihoglu M, Kurt O, Baskoy K, Altundag A, et al. Thyroid hormone replacement therapy improves olfaction and taste sensitivity in primary hypothyroid patients: a prospective randomised clinical trial. Experimental and Clinical Endocrinology & Diabetes 2016;124(9):562‐7. [DOI: 10.1055/s-0042-108446] - DOI - PubMed
Green 2013 {published data only}
    1. Green A, Kaul A, O'Shea J, Sharma E, Bennett L, Mullings EL, et al. Opiate agonists and antagonists modulate taste perception in opiate‐maintained and recently detoxified subjects. Journal of Psychopharmacology 2013;27(3):265‐75. - PubMed
Halyard 2007 {published data only}
    1. Halyard MY, Jatoi A, Sloan JA, Bearden JD 3rd, Vora SA, Atherton PJ, et al. Does zinc sulphate prevent therapy‐induced taste alterations in head and neck cancer patients? Results of phase III double‐blind, placebo‐controlled trial from the North Central Cancer Treatment Group (N01C4). International Journal of Radiation Oncology, Biology, Physics 2007;67(5):1318‐22. - PubMed
Hartman‐Petrycka 2016 {published data only}
    1. Hartman‐Petrycka M, Knefel G, Lebiedowska A, Kosmala J, Klimacka‐Nawrot E, Kawecki M, et al. Alterations in taste perception as a result of hyperbaric oxygen therapy. Appetite 2016;107:159‐65. - PubMed
Henkin 1976 {published data only}
    1. Henkin RI, Schecter PJ, Friedewald WT, Demets DL, Raff M. A double blind study of the effects of zinc sulphate on taste and smell dysfunction. American Journal of the Medical Sciences 1976;272(3):285‐99. - PubMed
Jham 2009 {published data only}
    1. Jham BC, Chen H, Carvalho AL, Freire AR. A randomized phase III prospective trial of bethanechol to prevent mucositis, candidiasis, and taste loss in patients with head and neck cancer undergoing radiotherapy: a secondary analysis. Journal of Oral Science 2009;51(4):565‐72. - PubMed
Kamphuis 2003 {published data only}
    1. Kamphuis MM, Saris WH, Westerterp‐Plantenga MS. The effect of addition of linoleic acid and food intake regulation in linoleic acid tasters and linoleic acid non‐tasters. British Journal of Nutrition 2003;90(1):199‐206. - PubMed
Lyckholm 2012 {published data only}
    1. Lyckholm L, Heddinger SP, Parker G, Coyne PJ, Ramakrishnan V, Smith TJ, et al. A randomized, placebo controlled trial of oral zinc for chemotherapy‐related taste and smell disorders. Journal of Pain and Palliative Care Pharmacotherapy 2012;26(2):111‐4. - PMC - PubMed
Mahajan 1992 {published data only}
    1. Mahajan SK, Prasad AS, Brewer G. Effect of changes in dietary zinc intake on taste acuity and dark adaptation in normal human subjects. Journal of Trace Elements in Experimental Medicine 1992;5(1):33‐45.
Najafizade 2013 {published data only}
    1. Najafizade N, Hemati S, Gookizade A, Berjis N, Hashemi M, Vejdani S, et al. Preventive effects of zinc sulphate on taste alterations in patients under irradiation for head and neck cancers: a randomized placebo‐controlled trial. Journal of Research in Medical Sciences 2013;18(2):123‐6. - PMC - PubMed
NCT01143285 {published data only}
    1. NCT01143285. Impact of early and active nutritional and dietary management grade 3 or more toxicities induced by chemotherapy and targeted therapies administered to patients as first intention for non surgical metastatic colorectal cancer (CHIMIODIET) [Chimiodiet study: impact of early and active nutritional and dietary management on grade 3 or mor toxicities induced by chemotherapy and targeted therapies administered to patients as first intention for non surgical metastatic colorectal cancer]. clinicaltrials.gov/show/NCT01143285 (first received 21 July 2009).
Ohno 2003 {published data only}
    1. Ohno T, Uematsu H, Nozaki S, Sugimoto K. Improvement of taste sensitivity of the nursed elderly by oral care. Journal of Medical and Dental Sciences 2003;50(1):101‐7. - PubMed
Ripamonti 1998 {published data only}
    1. Ripamonti C, Zecca E, Brunelli C, Fulfaro F, Villa S, Balzarini A, et al. A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation. Cancer 1998;82(10):1938‐45. - PubMed
Sprenger 1983 {published data only}
    1. Sprenger KB, Bundschu D, Lewis K, Spohn B, Schmitz J, Franz HE. Improvement of uremic neuropathy and hypogeusia by dialysate zinc supplementation: a double‐blind study. Kidney International. Supplement 1983;16:S315‐8. - PubMed
Stewart‐Knox 2008 {published data only}
    1. Stewart‐Knox BJ, Simpson EE, Parr H, Rae G, Polito A, Intorre F, et al. Taste acuity in response to zinc supplementation in older Europeans. British Journal of Nutrition 2008;99(1):129‐36. - PubMed
Strasser 2008 {published data only}
    1. Strasser F, Demmer R, Böhme C, Schmitz SF, Thuerlimann B, Cerny T, et al. Prevention of docetaxel‐ or paclitaxel‐associated taste alterations in cancer patients with oral glutamine: a randomized, placebo‐controlled, double‐blind study. Oncologist 2008;13(3):337‐46. - PubMed
Treldal 2016 {published data only}
    1. Treldal C, Jacobsen C B, Mogensen S, Rasmussen M, Jacobsen J, Petersen J, et al. Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome. Oral Diseases 2016;22(2):123‐31. - PubMed
Tupe 2009 {published data only}
    1. Tupe RP, Chiplonkar SA. Zinc supplementation improved cognitive performance and taste acuity in Indian adolescent girls. Journal of the American College of Nutrition 2009;28(4):388‐96. - PubMed
UMIN000027177 {published data only}
    1. UMIN000027177. A randomize[d] controlled trial on the efficacy of the cryotherapy for dysgeusia with docetaxel. upload.umin.ac.jp/cgi‐open‐bin/ctr_e/ctr_view.cgi?recptno=R000031119 (first received 28 April 2017).
Velargo 2012 {published data only}
    1. Velargo PA, Samant S. Synsepalum dulcificum and variable taste occurring after radiation (SAVOR) trial. www.researchposters.com/Posters/AAOHNSF/AAO2012/SP269.pdf (accessed 21 May 2014).
Yoshida 1991 {published data only}
    1. Yoshida S, Endo S, Tomita H. A double‐blind study of the therapeutic efficacy of zinc gluconate on taste disorder. Auris, Nasus, Larynx 1991;18(2):153‐61. - PubMed

References to studies awaiting assessment

JapicCTI‐121907 {published data only}
    1. JapicCTI‐121907. Z‐103 phase III clinical study in patients with taste disorder ‐ a placebo‐controlled superiority study. www.clinicaltrials.jp/user/showCteDetailE.jsp?japicId=JapicCTI‐121907 (first received 23 July 2012).
JPRN‐C000000401 {published data only}
    1. JPRN‐C000000401. Phase III clinical study on taste disorder by Z‐103 ‐ double‐blind comparison study on patients with zinc‐deficient and idiopathic taste disorders. apps.who.int/trialsearch/Trial.aspx?TrialID=JPRN‐C000000401 (first received 10 April 2006).
Mahajan 1979 {published data only}
    1. Mahajan SK, Prasad AS, Lambujon J, Abbasi AA, Briggs WA, McDonald FD. Improvement of uremic hypogeusia by zinc. Transactions ‐ American Society for Artificial Internal Organs 1979;25:443‐8. - PubMed
Sakai 2017 {published data only}
    1. Sakai C, Horikoshi Y, Abe S, Kozuki M, Shimohiro H, Ota Y, et al. Enhanced taste sensitivities in patients with type 2 diabetes receiving an oral preparation of high‐molecular‐weight fucoidan: fucose‐containing sulphated polysaccharides. 77th Scientific Sessions of the American Diabetes Association; 2017 June 9‐13; San Diego (Ca). professional.diabetes.org/content‐page/abstracts, 2017.
Sanchez 1993 {published data only}
    1. Sánchez Nebra J, Aníbarro García L, Vázquez Vizoso F, Carabelos Acuña P, Cristóbal García F, García Vázquez M, et al. Enteral nutrition and changes in taste in diabetic patients: a double‐blind prospective study. Nutricion Hospitalaria 1993;8(9):561‐6. - PubMed
Sturniolo 1985 {published data only}
    1. Sturniolo GC, Parisi G, Martin A, Lombardi F, Gurrieri G, Meani A, et al. Taste and smell alterations in liver cirrhosis: a double blind crossover trial of oral zinc treatment. Journal of Hepatology 1985;1(Suppl 1):s136.

References to ongoing studies

NCT02475928 {published data only}
    1. NCT02475928. Zinc supplementation in cirrhotic patients (ZnDCP) [Zinc supplementation as treatment of dysgeusias in cirrhotic patients]. clinicaltrials.gov/show/NCT02475928 (first received 19 June 2015).

Additional references

Aframian 2007
    1. Aframian DJ, Helcer M, Livni D, Robinson SD, Markitziu A, Nadler C. Pilocarpine treatment in a mixed cohort of xerostomic patients. Oral Diseases 2007;13(1):88‐92. - PubMed
Barrie 1987
    1. Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC. Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. Agents and Actions 1987;21(1‐2):223‐8. - PubMed
Bartoshuk 1994
    1. Bartoshuk LM, Duffy VB, Miller IJ. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiology & Behavior 1994;56(6):1165‐71. - PubMed
Bicknell 1988
    1. Bicknell JM, Wiggins RV. Taste disorder from zinc deficiency after tonsillectomy. Western Journal of Medicine 1988;149(4):457‐60. - PMC - PubMed
Birks 2009
    1. Birks J, Grimley Evans J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD003120.pub3] - DOI
Bromley 2000
    1. Bromley SM. Smell and taste disorders: a primary care approach. American Family Physician 2000;61(2):427‐38. - PubMed
de Moraes 2012
    1. Moraes M, do Amaral Bezerra BA, Rocha Neto PC, Oliveira Soares AC, Pinto LP, Lisboa Lopes Costa A. Randomized trials for the treatment of burning mouth syndrome: an evidence‐based review of the literature. Journal of Oral Pathology and Medicine 2012;41(4):281‐7. - PubMed
Deems 1991
    1. Deems DA, Doty RL, Settle RG, Moore‐Gillon V, Shaman P, Mester AF, et al. Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Archives of Otolaryngology ‐ Head & Neck Surgery 1991;117:519‐28. - PubMed
Femiano 2002
    1. Femiano F, Scully C, Gombos F. Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy. International Journal of Oral and Maxillofacial Surgery 2002;31(6):625‐8. - PubMed
Fikentscher 1987
    1. Fikentscher R, Gudziol H, Roseburg B. Classification and definition of smell and taste disorders. Laryngologie, Rhinologie, Otologie 1987;66(7):355‐7. - PubMed
Fujiyama 2010
    1. Fujiyama R, Ishitobi S, Honda K, Okada Y, Oi K, Toda K. Ice cube stimulation helps to improve dysgeusia. Odontology 2010;98(1):82‐4. - PubMed
Gardiner 2008
    1. Gardiner J, Overall R, Marc J. Do salivary neurotrophic factors provide neurotrophic support to neurons of the central and peripheral nervous systems including nerves innervating papillae on the tongue?. Bioscience Hypotheses 2008;1(5):251‐4.
Gondivkar 2009
    1. Gondivkar SM, Indurkar A, Degwekar S, Bhowate R. Evaluation of gustatory function in patients with diabetes mellitus type 2. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 2009;108(6):876‐80. - PubMed
GRADEpro GDT 2015 [Computer program]
    1. McMaster University (developed by Evidence Prime). GRADEpro GDT. Version accessed 1 August 2017. Hamilton (ON): McMaster University (developed by Evidence Prime), 2015.
Greenway 2011
    1. Greenway FL, Ingram DK, Ravussin E, Hausmann M, Smith SR, Cox L, et al. Loss of taste responds to high‐dose biotin treatment. Journal of the American College of Nutrition 2011;30(3):178‐81. - PMC - PubMed
Hawkes 2002
    1. Hawkes CH. The Most Common Complaints: Smell and Taste Complaints. 2nd Edition. Woburn, MA, USA: Butterworth‐Heinemann, Elsevier Science, 2002.
Henkin 1963
    1. Henkin RI, Gill JR, Bartter FC. Studies on taste thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids and of serum sodium concentration. Journal of Clinical Investigation 1963;42(5):727‐35. [PUBMED: 16695903] - PMC - PubMed
Henkin 1976
    1. Henkin RI, Schecter PJ, Friedewald WT, Demets DL, Raff M. A double blind study of the effects of zinc sulphate on taste and smell dysfunction. American Journal of the Medical Sciences 1976;272(3):285‐99. - PubMed
Henkin 1999
    1. Henkin RI, Martin BM, Agarwal RP. Efficacy of exogenous oral zinc in treatment of patients with carbonic anhydrase VI deficiency. American Journal of the Medical Sciences 1999;318(6):392‐405. - PubMed
Henkin 2000
    1. Henkin RI, Levy LM, Lin CS. Taste and smell phantoms revealed by brain functional MRI (fMRI). Journal of Computer Assisted Tomography 2000;24(1):106‐23. - PubMed
Henkin 2007
    1. Henkin RI, Velicu I, Papathanassiu A. cAMP and cGMP in human parotid saliva: relationships to taste and smell dysfunction, gender, and age. American Journal of the Medical Sciences 2007;334(6):431‐40. - PubMed
Henkin 2009
    1. Henkin RI, Velicu I. Decreased parotid salivary cyclic nucleotides related to smell loss severity in patients with taste and smell dysfunction. Metabolism 2009;58(12):1717‐23. - PubMed
Henkin 2010
    1. Henkin RI, Potolicchio SJ, Levy LM, Moharram R, Velicu I, Martin BM. Carbonic anhydrase I, II, and VI, blood plasma, erythrocyte and saliva zinc and copper increase after repetitive transcranial magnetic stimulation. American Journal of the Medical Sciences 2010;339(3):249‐57. - PMC - PubMed
Henkin 2011a
    1. Henkin RI, Potolicchio SJ Jr, Levy LM. Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation. American Journal of Otolaryngology 2011;32(1):38‐46. - PubMed
Henkin 2011b
    1. Henkin RI. Commentary on "transcranial magnetic stimulation: a treatment for smell and taste dysfunction". American Journal of Otolaryngology 2011;32(2):178‐80. - PubMed
Henkin 2012
    1. Henkin RI, Schultz M, Minnick‐Poppe L. Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of Otolaryngology ‐ Head & Neck Surgery 2012;138(11):1064‐70. - PubMed
Henkin 2013
    1. Henkin RI, Levy LM, Fordyce A. Taste and smell function in chronic disease: a review of clinical and biochemical evaluations of taste and smell dysfunction in over 5000 patients at The Taste and Smell Clinic in Washington, DC. American Journal of Otolaryngology 2013;34(5):477‐89. [DOI: 10.1016/j.amjoto.2013.04.006.; PUBMED: 23731850] - DOI - PubMed
Henkin 2014
    1. Henkin RI. Effects of smell loss (hyposmia) on salt usage. Nutrition 2014;30(6):690‐5. - PubMed
Higgins 2011
    1. Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
Hovan 2010
    1. Hovan AJ, Williams PM, Stevenson‐Moore P, Wahlin YB, Ohrn KE, Elting LS, et al. A systematic review of dysgeusia induced by cancer therapies. Supportive Care in Cancer 2010;18(8):1081‐7. [PUBMED: 20495984] - PubMed
Ikeda 2005
    1. Ikeda M, Aiba T, Ikui A, Inokuchi A, Kurono Y, Sakagami M, et al. Taste disorders: a survey of the examination methods and treatments used in Japan. Acta Oto‐Laryngologica 2005;125(11):1203‐10. - PubMed
Imoscopi 2012
    1. Imoscopi A, Inelmen EM, Sergi G, Miotto F, Manzato E. Taste loss in the elderly: epidemiology, causes and consequences. Aging Clinical and Experimental Research 2012;24(6):570‐9. [DOI: 10.3275/8520; PUBMED: 22828477] - DOI - PubMed
Ishimaru 2001
    1. Ishimaru T, Hatanaka S, Miwa T, Furukawa M. Clinical bitterness masking test for phantogeusia. Chemical Senses 2001;26(1):91‐3. - PubMed
Iwatsuki 2012
    1. Iwatsuki K, Uneyama H. Sense of taste in the gastrointestinal tract. Journal of Pharmacological Sciences 2012;118(2):123‐8. - PubMed
Kashihara 2011
    1. Kashihara K, Hanaoka A, Imamura T. Frequency and characteristics of taste impairment in patients with Parkinson's disease: results of a clinical interview. Internal Medicine 2011;50(20):2311‐5. - PubMed
Kinnamon 2012
    1. Kinnamon SC. Taste receptor signalling ‐ from tongues to lungs. Acta Physiologica 2012;204(2):158‐68. - PMC - PubMed
Leek 2002
    1. Leek H, Albertsson M. Pilocarpine treatment of xerostomia in head and neck patients. Micron 2002;33(2):153‐5. - PubMed
Lefebvre 2011
    1. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
Mattes 2004
    1. Mattes RD, Pawlik MK. Effects of Ginkgo biloba on alertness and chemosensory function in healthy adults. Human Psychopharmacology 2004;19(2):81‐90. - PubMed
Mattes 2009
    1. Mattes RD. Is there a fatty acid taste?. Annual Review of Nutrition 2009;29:305‐27. - PMC - PubMed
McLaughlin 2014
    1. McLaughlin L, Mahon S. A meta‐analysis of the relationship among impaired taste and treatment, treatment type, and tumor site in head and neck cancer treatment survivors. Oncology Nursing Forum 2014;41(3):E194‐202. [DOI: 10.1188/14.ONF.E194-E202; PUBMED: 24769602] - DOI - PubMed
Miller 1995
    1. Miller IJ. Anatomy of the peripheral taste system. In: Doty RL editor(s). Handbook of Olfaction and Gustation. NY: Marcel Dekker, 1995:521‐47.
Mistretta 1984
    1. Mistretta CM, Baum BJ. Quantitative study of taste buds in fungiform and circumvallate papillae of young and aged rats. Journal of Anatomy 1984;138 (Pt 2):323‐32. - PMC - PubMed
Mossman 1978
    1. Mossman KL, Henkin RI. Radiation‐induced changes in taste acuity in cancer patients. International Journal of Radiation Oncology, Biology, Physics 1978;4(7‐8):663‐70. - PubMed
Mueller 2003
    1. Mueller C, Kallert S, Renner B, Stiassny K, Temmel AF, Hummel T, et al. Quantitative assessment of gustatory function in a clinical context using impregnated "taste strips". Rhinology 2003;41(1):2‐6. [PUBMED: 12677732] - PubMed
Nagao 2010
    1. Nagao Y, Matsuoka H, Kawaguchi T, Sata M. Aminofeel improves the sensitivity to taste in patients with HCV‐infected liver disease. Medical Science Monitor 2010;16(4):PI7‐12. - PubMed
NIDCD 2009
    1. National Institute on Deafness and other Communication Disorders. NIDCD fact sheet: taste disorders. www.nidcr.nih.gov/oralhealth/Topics/TasteDisorders/Documents/TasteDisord... (accessed 27 January 2013).
NIDCD 2010
    1. National Institute on Deafness and other Communication Disorders. Quick statistics about taste and smell. www.nidcd.nih.gov/health/statistics/smelltaste/Pages/stquickstats.aspx (accessed 27 January 2013).
Ohnuki 2014
    1. Ohnuki M, Ueno M, Zaitsu T, Kawaguchi Y. Taste hyposensitivity in Japanese schoolchildren. BMC Oral Health 2014;14:36. [DOI: 10.1186/1472-6831-14-36; PUBMED: 24725841] - DOI - PMC - PubMed
Padala 2006
    1. Padala KP, Hinners CK, Padala PR. Mirtazapine therapy for dysgeusia in an elderly patient. Primary Care Companion to the Journal of Clinical Psychiatry 2006; Vol. 8, issue 3:178‐80. - PMC - PubMed
Porter 2010
    1. Porter SR, Fedele S, Habbab KM. Taste dysfunction in head and neck malignancy. Oral Oncology 2010;46(6):457‐9. - PubMed
Rawal 2016
    1. Rawal S, Hoffman HJ, Bainbridge KE, Huedo‐Medina TB, Duffy VB. Prevalence and risk factors of self‐reported smell and taste alterations: results from the 2011–2012 US National Health and Nutrition Examination Survey (NHANES). Chemical Senses 2016;41(1):69‐76. - PMC - PubMed
Review Manager 2014 [Computer program]
    1. Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager 5 (RevMan 5). Version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
Russell 1980
    1. Russell RM. Vitamin A and zinc metabolism in alcoholism. American Journal of Clinical Nutrition 1980;33(12):2741‐9. - PubMed
Sasano 2010
    1. Sasano T, Satoh‐Kuriwada S, Shoji N, Sekine‐Hayakawa Y, Kawai M, Uneyama H. Application of umami taste stimulation to remedy hypogeusia based on reflex salivation. Biological and Pharmaceutical Bulletin 2010;33(11):1791‐5. - PubMed
Sergi 2017
    1. Sergi G, Bano G, Pizzato S, Veronese N, Manzato E. Taste loss in the elderly: possible implications for dietary habits. Critical Reviews in Food Science and Nutrition 2017;57(17):3684‐9. - PubMed
Silverman 1983
    1. Silverman JE, Weber CW, Silverman S Jr, Coulthard SL, Manning MR. Zinc supplementation and taste in head and neck cancer patients undergoing radiation therapy. Journal of Oral Medicine 1983;38(1):14‐6. - PubMed
Smutzer 2008
    1. Smutzer G, Lam S, Hastings L, Desai H, Abarintos RA, Sobel M, et al. A test for measuring gustatory function. Laryngoscope 2008;118(8):1411‐6. - PMC - PubMed
Solomons 1974
    1. Solomons N, Khactu K, Sandstead H, Rosenberg I. Zinc nutrition in regional enteritis (RE). Clinical Research 1974;22:582–9.
Soter 2008
    1. Soter A, Kim J, Jackman A, Tourbier I, Kaul A, Doty RL. Accuracy of self‐report in detecting taste dysfunction. Laryngoscope 2008;118(4):611‐7. - PubMed
Spielman 1992
    1. Spielman AI, Ricketts DA, Brand JG. High resolution scanning electron micrographic study of dissociated mouse taste cells. Chemical Senses 1992;17(4):451‐60.
Tomita 1986
    1. Tomita H, Ikeda M, Okuda Y. Basis and practice of clinical taste examinations. Auris, Nasus, Larynx 1986;13 Suppl 1:S1‐15. - PubMed
Vent 2010
    1. Vent J, Wang DW, Damm M. Effects of traditional Chinese acupuncture in post‐viral olfactory dysfunction. Otolaryngology ‐ Head and Neck Surgery 2010;142(4):505‐9. - PubMed
Wickham 1999
    1. Wickham RS, Rehwaldt M, Kefer C, Shott S, Abbas K, Glynn‐Tucker E, et al. Taste changes experienced by patients receiving chemotherapy. Oncology Nursing Forum 1999;26(4):697‐706. - PubMed
Wilken 2012
    1. Wilken MK, Satiroff BA. Pilot study of "miracle fruit" to improve food palatability for patients receiving chemotherapy. Clinical Journal of Oncology Nursing 2012;16(5):E173‐7. - PubMed
Winkler 1999
    1. Winkler S, Garg AK, Mekayarajjananonth T, Bakaeen LG, Khan E. Depressed taste and smell in geriatric patients. Journal of the American Dental Association 1999;130(12):1759‐65. - PubMed

References to other published versions of this review

Kumbargere 2013
    1. Sumanth Kumbargere N, Naresh YS, Srinivas K, Renjith George P, Shrestha A, Levenson D, Ferraiolo DM. Interventions for the management of taste disturbances. Cochrane Database of Systematic Reviews 2013, Issue 4. [DOI: 10.1002/14651858.CD010470] - DOI - PubMed
Kumbargere 2014
    1. Kumbargere Nagraj S, Naresh S, Srinivas K, Renjith George P, Shrestha A, Levenson D, Ferraiolo DM. Interventions for the management of taste disturbances. Cochrane Database of Systematic Reviews 2014, Issue 11. [CENTRAL: CD010470; DOI: 10.1002/14651858.CD010470] - DOI - PubMed

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