Neostigmine

Excerpt

Neostigmine is a water-soluble, ionized compound that reversibly inhibits acetylcholinesterase and is an FDA-approved agent for reversing non-depolarizing neuromuscular blockade after surgery. This drug demonstrates a short duration of action, minimal penetration across the blood-brain barrier, and targeted activity at neuromuscular junctions. Adverse effects associated with neostigmine administration include bradycardia, hypersalivation, bronchoconstriction, and increased gastrointestinal motility, whereas contraindications include mechanical obstruction of the gastrointestinal or urinary tract. This activity addresses indications, mechanism of action, adverse effects, contraindications, pharmacokinetics, dosing, relevant drug interactions, and adverse effect profiles within a clinical framework.