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Book

Sick Sinus Syndrome

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan.
.
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Book

Sick Sinus Syndrome

Wael Dakkak et al.
Free Books & Documents

Excerpt

Sick sinus syndrome, also known as sinus node dysfunction (SND), is a disorder of the sinoatrial (SA) node caused by impaired pacemaker function and impulse transmission producing a constellation of abnormal rhythms. These include atrial bradyarrhythmias, atrial tachyarrhythmias and, sometimes, bradycardia alternating with tachycardia often referred to as “tachy-brady syndrome.” These arrhythmias may result in palpitations and tissue under-perfusion leading to fatigue, lightheadedness, pre-syncope, and syncope.

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Conflict of interest statement

Disclosure: Wael Dakkak declares no relevant financial relationships with ineligible companies.

Disclosure: Rami Doukky declares no relevant financial relationships with ineligible companies.

References

    1. Semelka M, Gera J, Usman S. Sick sinus syndrome: a review. Am Fam Physician. 2013 May 15;87(10):691-6. - PubMed
    1. Dobrzynski H, Boyett MR, Anderson RH. New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation. 2007 Apr 10;115(14):1921-32. - PubMed
    1. Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 09;342(10):703-9. - PubMed
    1. Adán V, Crown LA. Diagnosis and treatment of sick sinus syndrome. Am Fam Physician. 2003 Apr 15;67(8):1725-32. - PubMed
    1. Rosenqvist M, Obel IW. Atrial pacing and the risk for AV block: is there a time for change in attitude? Pacing Clin Electrophysiol. 1989 Jan;12(1 Pt 1):97-101. - PubMed

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