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Book

Typhoid Vaccine

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Typhoid Vaccine

Roscoe O. Van Camp et al.
Free Books & Documents

Excerpt

This educational activity discusses vaccinations against typhoid, detailing their indications, mechanisms, administration methods, adverse effects, contraindications, and the rationale for use in both endemic and nonendemic areas. This activity aids healthcare providers in effectively recommending and administering typhoid vaccines when appropriate. In the United States and other high-income countries, these vaccines are typically given to travelers, laboratory workers, and individuals in close contact with patients with Salmonella serotype Typhi infections. Poor water, sanitation, and hygiene infrastructure in endemic regions contribute to high infection rates. The World Health Organization (WHO) recommends routine vaccination for children aged 6 months to 15 years in these areas, particularly those facing outbreaks of drug-resistant strains of S Typhi.

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Conflict of interest statement

Disclosure: Roscoe Van Camp declares no relevant financial relationships with ineligible companies.

Disclosure: Mahmoud Shorman declares no relevant financial relationships with ineligible companies.

References

    1. Batool R, Qamar ZH, Salam RA, Yousafzai MT, Ashorn P, Qamar FN. Efficacy of typhoid vaccines against culture-confirmed Salmonella Typhi in typhoid endemic countries: a systematic review and meta-analysis. Lancet Glob Health. 2024 Apr;12(4):e589-e598. - PubMed
    1. GRAM Typhoid Collaborators. Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990-2019: a modelling study. Lancet Glob Health. 2024 Mar;12(3):e406-e418. - PMC - PubMed
    1. Jackson BR, Iqbal S, Mahon B, Centers for Disease Control and Prevention (CDC) Updated recommendations for the use of typhoid vaccine--Advisory Committee on Immunization Practices, United States, 2015. MMWR Morb Mortal Wkly Rep. 2015 Mar 27;64(11):305-8. - PMC - PubMed
    1. World Health Organization Typhoid vaccines: WHO position paper, March 2018 - Recommendations. Vaccine. 2019 Jan 07;37(2):214-216. - PubMed
    1. Britto CD, Wong VK, Dougan G, Pollard AJ. A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid. PLoS Negl Trop Dis. 2018 Oct;12(10):e0006779. - PMC - PubMed

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