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Book

Lamotrigine

Nicholas T. Betchel  1 , Kamron A. Fariba  2 , Abdolreza Saadabadi  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Lamotrigine

Nicholas T. Betchel et al.
Free Books & Documents

Excerpt

Lamotrigine can be used to treat the following partial seizures, primary generalized tonic-clonic seizures, bipolar I disorder maintenance and Lennox-Gastaut syndrome. Off-label uses include treating acute bipolar depression, fibromyalgia, schizophrenia, and unipolar depression. This activity covers lamotrigine, including mechanism of action, pharmacology, adverse event profiles, eligible patient populations, contraindications, monitoring, and highlights the interprofessional team's role in managing lamotrigine therapy.

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Conflict of interest statement

Disclosure: Nicholas Betchel declares no relevant financial relationships with ineligible companies.

Disclosure: Kamron Fariba declares no relevant financial relationships with ineligible companies.

Disclosure: Abdolreza Saadabadi declares no relevant financial relationships with ineligible companies.

References

    1. Jansen AC, Andermann E. Progressive Myoclonus Epilepsy, Lafora Type. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet] University of Washington, Seattle; Seattle (WA): 2007. Dec 28, - PubMed
    1. Brigo F, Igwe SC, Lattanzi S. Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents. Cochrane Database Syst Rev. 2019 Feb 08;2(2):CD003032. - PMC - PubMed
    1. Brigo F, Jones K, Eltze C, Matricardi S. Anti-seizure medications for Lennox-Gastaut syndrome. Cochrane Database Syst Rev. 2021 Apr 07;4(4):CD003277. - PMC - PubMed
    1. Köhler-Forsberg O, Sylvia LG, Thase M, Calabrese JR, Tohen M, Bowden CL, McInnis M, Iosifescu DV, Kocsis JH, Friedman ES, Ketter TA, McElroy SL, Shelton RC, Fung V, Ostacher MJ, Nierenberg AA. Lithium plus antipsychotics or anticonvulsants for bipolar disorder: Comparing clinical response and metabolic changes. Aust N Z J Psychiatry. 2023 Jan;57(1):93-103. - PubMed
    1. Ranganathan LN, Ramamurthy G, Kanthimathinathan S. Preventive Oral Treatment of Episodic Migraine: An Overview. Neurol India. 2021 Mar-Apr;69(Supplement):S51-S58. - PubMed

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