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Book

Alcoholic-Associated Hepatitis

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Alcoholic-Associated Hepatitis

Niraj J. Shah et al.
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Excerpt

Excessive alcohol consumption could result in fatty liver disease or steatosis, alcoholic hepatitis (AH), and eventually cirrhosis. Alcoholic hepatitis is a severe syndrome of alcoholic liver disease (ALD), characterized by rapid onset of jaundice, malaise, tender hepatomegaly, and subtle features of systemic inflammatory response. The recent worsening profile and trends of patients with AH-related hospitalizations in the United States suggest its importance in the current realm of clinical practice with its subsequent management.

Alcoholic hepatitis usually progresses to cirrhosis if drinking is continued. For those who discontinue alcohol, hepatitis returns to normal within a few months but the cirrhosis that has already occurred does not reverse.

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Conflict of interest statement

Disclosure: Niraj Shah declares no relevant financial relationships with ineligible companies.

Disclosure: Amor Royer declares no relevant financial relationships with ineligible companies.

Disclosure: Savio John declares no relevant financial relationships with ineligible companies.

References

    1. Im GY, Cameron AM, Lucey MR. Liver transplantation for alcoholic hepatitis. J Hepatol. 2019 Feb;70(2):328-334. - PubMed
    1. Gustot T, Jalan R. Acute-on-chronic liver failure in patients with alcohol-related liver disease. J Hepatol. 2019 Feb;70(2):319-327. - PubMed
    1. Mathurin P, Thursz M. Endpoints and patient stratification in clinical trials for alcoholic hepatitis. J Hepatol. 2019 Feb;70(2):314-318. - PubMed
    1. Singal AK, Shah VH. Current trials and novel therapeutic targets for alcoholic hepatitis. J Hepatol. 2019 Feb;70(2):305-313. - PubMed
    1. Gao B, Ahmad MF, Nagy LE, Tsukamoto H. Inflammatory pathways in alcoholic steatohepatitis. J Hepatol. 2019 Feb;70(2):249-259. - PMC - PubMed

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