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Book

Bupropion

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Bupropion

Martin R. Huecker et al.
Free Books & Documents

Excerpt

Bupropion is an antidepressant medication that has received FDA approval for the treatment of depression and seasonal affective disorder and as an aid for smoking cessation. Since its approval in 1985, bupropion has been utilized off-label for various conditions, including antidepressant-induced sexual dysfunction, depression associated with bipolar disorder, obesity, and ADHD in pediatric patients. This activity reviews bupropion's clinical applications, including indications, dosing, mechanism of action, adverse event profile, and toxicity. By understanding bupropion's pharmacological properties, healthcare professionals can optimize treatment regimens and reduce the risk of adverse effects, thereby improving patient outcomes. The activity also emphasizes the essential role of the interprofessional healthcare team in managing bupropion therapy, underlining the significance of collaboration and well-defined roles in patient care.

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Conflict of interest statement

Disclosure: Martin Huecker declares no relevant financial relationships with ineligible companies.

Disclosure: Abbey Smiley declares no relevant financial relationships with ineligible companies.

Disclosure: Abdolreza Saadabadi declares no relevant financial relationships with ineligible companies.

References

    1. Settle EC. Bupropion sustained release: side effect profile. J Clin Psychiatry. 1998;59 Suppl 4:32-6. - PubMed
    1. Jefferson JW. Bupropion extended-release for depressive disorders. Expert Rev Neurother. 2008 May;8(5):715-22. - PubMed
    1. Wilkes S. Bupropion. Drugs Today (Barc) 2006 Oct;42(10):671-81. - PubMed
    1. Hsieh MT, Tseng PT, Wu YC, Tu YK, Wu HC, Hsu CW, Lei WT, Stubbs B, Carvalho AF, Liang CS, Yeh TC, Chen TY, Chu CS, Li JC, Yu CL, Chen YW, Li DJ. Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta-analysis. Obes Rev. 2019 Jun;20(6):895-905. - PubMed
    1. Hankosky ER, Bush HM, Dwoskin LP, Harris DR, Henderson DW, Zhang GQ, Freeman PR, Talbert JC. Retrospective analysis of health claims to evaluate pharmacotherapies with potential for repurposing: Association of bupropion and stimulant use disorder remission. AMIA Annu Symp Proc. 2018;2018:1292-1299. - PMC - PubMed

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