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Comment
. 2017 Dec 19;47(6):1009-1011.
doi: 10.1016/j.immuni.2017.11.028.

Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells

Vijaykumar Chennupati  1 , Werner Held  2
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Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells

Vijaykumar Chennupati et al. Immunity. .
Free article

Abstract

The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2017) and Wu et al. (2017) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion in response to tissue allografts.

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