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Review
. 2017 Sep 29:2:17040.
doi: 10.1038/sigtrans.2017.40. eCollection 2017.

Targeting cellular pathways in glioblastoma multiforme

Joshua R D Pearson  1 , Tarik Regad  1
Affiliations
Review

Targeting cellular pathways in glioblastoma multiforme

Joshua R D Pearson et al. Signal Transduct Target Ther. .

Abstract

Glioblastoma multiforme (GBM) is a debilitating disease that is associated with poor prognosis, short median patient survival and a very limited response to therapies. GBM has a very complex pathogenesis that involves mutations and alterations of several key cellular pathways that are involved in cell proliferation, survival, migration and angiogenesis. Therefore, efforts that are directed toward better understanding of GBM pathogenesis are essential to the development of efficient therapies that provide hope and extent patient survival. In this review, we outline the alterations commonly associated with GBM pathogenesis and summarize therapeutic strategies that are aimed at targeting aberrant cellular pathways in GBM.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of RTK activation and the resultant downstream signaling. Black arrows indicate activation whereas red arrows indicate inhibition.
Figure 2
Figure 2
A schematic representation of the role of p53 and pRB signaling in response to stress signals. Black arrows indicate activation whereas red arrows indicate inhibition.
See this image and copyright information in PMC

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