CDC Grand Rounds: National Amyotrophic Lateral Sclerosis (ALS) Registry Impact, Challenges, and Future Directions
- PMID: 29267263
- PMCID: PMC5751576
- DOI: 10.15585/mmwr.mm6650a3
CDC Grand Rounds: National Amyotrophic Lateral Sclerosis (ALS) Registry Impact, Challenges, and Future Directions
Erratum in
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Erratum: Vol. 66, No. 50.MMWR Morb Mortal Wkly Rep. 2018 Jan 19;67(2):81. doi: 10.15585/mmwr.mm6702a8. MMWR Morb Mortal Wkly Rep. 2018. PMID: 29346341 Free PMC article. No abstract available.
Abstract
Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, is a rapidly progressive fatal neurologic disease. Currently, there is no cure for ALS and the available treatments only extend life by an average of a few months. The majority of ALS patients die within 2-5 years of diagnosis, though survival time varies depending on disease progression (1,2). For approximately 10% of patients, ALS is familial, meaning it and has a genetic component; the remaining 90% have sporadic ALS, where etiology is unknown, but might be linked to environmental factors such as chemical exposures (e.g., heavy metals, pesticides) and occupational history (3).
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References
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- Miller RG, Jackson CE, Kasarskis EJ, et al.; Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2009;73:1218–26. 10.1212/WNL.0b013e3181bc0141 - DOI - PMC - PubMed
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- Miller RG, Jackson CE, Kasarskis EJ, et al.; Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2009;73:1227–33. 10.1212/WNL.0b013e3181bc01a4 - DOI - PMC - PubMed
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- US Public Health Service. ALS Registry Act. Washington, DC: 110th Congress. Public Law 2008;122 Stat 4047:110–373.
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