The search continues: neuroprotection for all neonates with hypoxic-ischemic encephalopathy

Jennifer K Lee^{1

2}, An N Massaro³, Frances J Northington^{2

4}

Affiliations

¹ Division of Pediatric Anesthesiology, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
² Neurosciences Intensive Care Nursery, Johns Hopkins University, Baltimore, MD, USA.
³ Division of Neonatology, Department of Pediatrics, Children's National Health Systems, The George Washington University School of Medicine, Washington D.C., USA.
⁴ Division of Neonatology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.

PMID: 29268339
PMCID: PMC5723838
DOI: 10.21037/jtd.2017.09.64

Editorial

The search continues: neuroprotection for all neonates with hypoxic-ischemic encephalopathy

Jennifer K Lee et al. J Thorac Dis. 2017 Oct.

. 2017 Oct;9(10):3553-3536.

doi: 10.21037/jtd.2017.09.64.

Authors

Jennifer K Lee^{1

2}, An N Massaro³, Frances J Northington^{2

4}

Affiliations

¹ Division of Pediatric Anesthesiology, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
² Neurosciences Intensive Care Nursery, Johns Hopkins University, Baltimore, MD, USA.
³ Division of Neonatology, Department of Pediatrics, Children's National Health Systems, The George Washington University School of Medicine, Washington D.C., USA.
⁴ Division of Neonatology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.

PMID: 29268339
PMCID: PMC5723838
DOI: 10.21037/jtd.2017.09.64

No abstract available

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Conflict of interest statement

Conflicts of Interest: Dr. Lee and Dr. Northington received research support from Medtronic for a separate study. Dr. Lee was also a paid advisory board member for Medtronic. This arrangement has been reviewed and approved by the Johns Hopkins University in accordance with its conflict of interest policies.

Comment on

Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial.
Shankaran S, Laptook AR, Pappas A, McDonald SA, Das A, Tyson JE, Poindexter BB, Schibler K, Bell EF, Heyne RJ, Pedroza C, Bara R, Van Meurs KP, Huitema CMP, Grisby C, Devaskar U, Ehrenkranz RA, Harmon HM, Chalak LF, DeMauro SB, Garg M, Hartley-McAndrew ME, Khan AM, Walsh MC, Ambalavanan N, Brumbaugh JE, Watterberg KL, Shepherd EG, Hamrick SEG, Barks J, Cotten CM, Kilbride HW, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Shankaran S, et al. JAMA. 2017 Jul 4;318(1):57-67. doi: 10.1001/jama.2017.7218. JAMA. 2017. PMID: 28672318 Free PMC article. Clinical Trial.

References

1. Azzopardi D, Strohm B, Marlow N, et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med 2014;371:140-9. 10.1056/NEJMoa1315788 - DOI - PubMed
1. Shankaran S, Pappas A, McDonald SA, et al. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 2012;366:2085-92. 10.1056/NEJMoa1112066 - DOI - PMC - PubMed
1. Shankaran S, Laptook AR, Pappas A, et al. Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial. JAMA 2014;312:2629-39. 10.1001/jama.2014.16058 - DOI - PMC - PubMed
1. Shankaran S, Laptook AR, Pappas A, et al. Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. JAMA 2017;318:57-67. 10.1001/jama.2017.7218 - DOI - PMC - PubMed
1. Wood T, Osredkar D, Puchades M, et al. Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia. Sci Rep 2016;6:23430. 10.1038/srep23430 - DOI - PMC - PubMed

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The search continues: neuroprotection for all neonates with hypoxic-ischemic encephalopathy

Affiliations

The search continues: neuroprotection for all neonates with hypoxic-ischemic encephalopathy

Authors

Affiliations

Conflict of interest statement

Comment on

References

Publication types

LinkOut - more resources

Full Text Sources

Other Literature Sources