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Editorial
. 2017 Oct;9(10):3560-3563.
doi: 10.21037/jtd.2017.09.76.

The challenge of co-existent moderate aortic stenosis and left ventricular systolic impairment

Russell J Everett  1 , Marc R Dweck  1 , Nicholas L M Cruden  1
Affiliations
Editorial

The challenge of co-existent moderate aortic stenosis and left ventricular systolic impairment

Russell J Everett et al. J Thorac Dis. 2017 Oct.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The potential impact of coexistent left ventricular dysfunction on the natural history of calcific aortic stenosis (AS). Following an asymptomatic period of progressive valvular stenosis and increasing left ventricular afterload, the onset of symptoms indicates left ventricle (LV) decompensation with a mortality of over 50% within 2–3 years unless valve replacement is performed. Where the LV is already failing due to other myocardial pathology, the increased afterload associated with even moderate AS may be poorly tolerated and lead to a more rapid decline and the earlier development of symptoms and adverse events.
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Comment on

References

    1. Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) , European Association for Cardio-Thoracic Surgery (EACTS), Vahanian A, et al. Guidelines on the management of valvular heart disease (version 2012). Eur Heart J 2012;33:2451-96. 10.1093/eurheartj/ehs109 - DOI - PubMed
    1. Lancellotti P, Magne J, Donal E, et al. Clinical outcome in asymptomatic severe aortic stenosis: insights from the new proposed aortic stenosis grading classification. J Am Coll Cardiol 2012;59:235-43. 10.1016/j.jacc.2011.08.072 - DOI - PubMed
    1. van Gils L, Clavel MA, Vollema EM, et al. Prognostic Implications of Moderate Aortic Stenosis in Patients With Left Ventricular Systolic Dysfunction. J Am Coll Cardiol 2017;69:2383-92. 10.1016/j.jacc.2017.03.023 - DOI - PubMed
    1. McMurray JJ, Packer M, Desai AS, et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med 2014;371:993-1004. 10.1056/NEJMoa1409077 - DOI - PubMed
    1. McMurray JJ, Krum H, Abraham WT, et al. Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure. N Engl J Med 2016;374:1521-32. 10.1056/NEJMoa1514859 - DOI - PubMed

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