Prophylactic cranial irradiation for stage IV small cell lung cancer, live longer or reduce morbidity of brain metastases?

Affiliations

¹ Department of Medical Oncology, Clatterbridge Cancer Centre, Liverpool Heart & Chest Hospital, University of Liverpool, Liverpool, UK.
² Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Editorial

Pieter E Postmus et al. J Thorac Dis. 2017 Oct.

. 2017 Oct;9(10):3572-3575.

doi: 10.21037/jtd.2017.09.50.

¹ Department of Medical Oncology, Clatterbridge Cancer Centre, Liverpool Heart & Chest Hospital, University of Liverpool, Liverpool, UK.
² Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial.
Takahashi T, Yamanaka T, Seto T, Harada H, Nokihara H, Saka H, Nishio M, Kaneda H, Takayama K, Ishimoto O, Takeda K, Yoshioka H, Tachihara M, Sakai H, Goto K, Yamamoto N. Takahashi T, et al. Lancet Oncol. 2017 May;18(5):663-671. doi: 10.1016/S1470-2045(17)30230-9. Epub 2017 Mar 23. Lancet Oncol. 2017. PMID: 28343976 Clinical Trial.

1. Takahashi T, Yamanaka T, Seto T, et al. Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 2017;18:663-71. 10.1016/S1470-2045(17)30230-9 - DOI - PubMed
1. Nugent JL, Bunn PA, Jr, Matthews MJ, et al. CNS metastases in small cell bronchogenic carcinoma: increasing frequency and changing pattern with lengthening survival. Cancer 44:1885-93. 10.1002/1097-0142(197911)44:5<1885::AID-CNCR2820440550>3.0.CO;2-F - DOI - PubMed
1. Seute T, Leffers P, ten Velde GP, Twijnstra A. Detection of brain metastases from small cell lung cancer: consequences of changing imaging techniques (CT versus MRI). Cancer 2008;112:1827-34. 10.1002/cncr.23361 - DOI - PubMed
1. Felletti R, Souhami RL, Spiro SG, et al. Social consequences of brain or liver relapse in small cell carcinoma of the bronchus. Radiother Oncol 1985;4:335-9. 10.1016/S0167-8140(85)80121-3 - DOI - PubMed
1. Kristjansen PE, Kristensen CA. The role of prophylactic cranial irradiation in the management of small cell lung cancer. Cancer Treat Rev 1993;19:3-16. 10.1016/0305-7372(93)90023-K - DOI - PubMed