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Editorial
. 2017 Nov;9(11):4197-4200.
doi: 10.21037/jtd.2017.10.15.

Tumor-associated macrophages-additional effectors at anti-PD-1/PD-L1 therapy?

Kenichi Suda  1   2
Affiliations
Editorial

Tumor-associated macrophages-additional effectors at anti-PD-1/PD-L1 therapy?

Kenichi Suda. J Thorac Dis. 2017 Nov.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Model of action of anti-PD-1/PD-L1 immunotherapy in tumor cells—T cells interaction theory. Tumor cells that express PD-L1 suppress cytotoxic function of PD-1 positive activated T cells through the PD-L1/PD-1 interaction. Therefore, the blockade of this pathway by anti-PD-1 drugs or by anti-PD-L1 drugs enables T cells to counterattack tumor cells.
Figure 2
Figure 2
Model of action of anti-PD-1/PD-L1 immunotherapy focusing on tumor cells, cytotoxic T cells, and tumor associated macrophages (TAMs). PD-1 is expressed not only in T cells, but also in TAMs, leading these cells to become inactivated upon binding to PD-L1 expressed on tumor cells. TAMs (M2 TAMs) also express PD-L1 and the ligand for the death receptor FAS that inactivates T cells and triggers caspase-dependent cell death in T cells, respectively (left). Treatment with an anti-PD-1 or anti-PD-L1 monoclonal antibody drug not only activates cytotoxic T cells, but also affects TAMs so that they increase phagocytic potency against tumor cells (right).
See this image and copyright information in PMC

Comment on

References

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