Comment
doi: 10.1016/j.tim.2017.12.003.
Influenza H3N2 Vaccines: Recent Challenges
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- PMID: 29268980
- DOI: 10.1016/j.tim.2017.12.003
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Comment
Influenza H3N2 Vaccines: Recent Challenges
Trends Microbiol.
2018 Feb.
Abstract
H3N2-subtype influenza A viruses are major causes of seasonal influenza epidemics. Emerging H3N2 variants require the annual adjustment of the vaccine strain. Recently, studies addressing the reduced effectiveness of current H3N2 vaccines have identified production-related substitutions in the viral hemagglutinin antigen as a possible cause for reduced vaccine efficacy.
Keywords: H3N2 subtype; HA glycosylation; influenza vaccine; influenza virus.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Comment on
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A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.PLoS Pathog. 2017 Oct 23;13(10):e1006682. doi: 10.1371/journal.ppat.1006682. eCollection 2017 Oct. PLoS Pathog. 2017. PMID: 29059230 Free PMC article.
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Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12578-12583. doi: 10.1073/pnas.1712377114. Epub 2017 Nov 6. Proc Natl Acad Sci U S A. 2017. PMID: 29109276 Free PMC article.
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