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Review
. 2018 Mar;26(3):172-174.
doi: 10.1016/j.tim.2017.12.001.

Do Archaea Need an Origin of Replication?

Lori M Kelman  1 , Zvi Kelman  2
Affiliations
Review

Do Archaea Need an Origin of Replication?

Lori M Kelman et al. Trends Microbiol. 2018 Mar.

Abstract

Chromosomal DNA replication starts at a specific region called an origin of replication. Until recently, all organisms were thought to require origins to replicate their chromosomes. It was recently discovered that some archaeal species do not utilize origins of replication under laboratory growth conditions.

Keywords: DNA replication; archaea; genetics; initiation of DNA replication; origin of replication; recombination-dependent DNA replication.

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References

    1. Boulikas T (1996) Common structural features of replication origins in all life forms. J Cell Biochem 60 (3), 297–316. - PubMed
    1. Lopez P et al. (1999) Identification of putative chromosomal origins of replication in Archaea. Mol Microbiol 32 (4), 883–886. - PubMed
    1. Myllykallio H et al. (2000) Bacterial mode of replication with eukaryotic-like machinery in a hyperthermophilic archaeon. Science 288 (5474), 2212–2215. - PubMed
    1. Kelman Z (2000) The replication origin of archaea is finally revealed. Trends Biochem Sci 25 (11), 521–523. - PubMed
    1. Matsunaga F et al. (2001) In vivo interactions of archaeal Cdc6/Orc1 and minichromosome maintenance protein with the replication origin. Proc Natl Acad Sci U S A 98 (20), 11152–11157. - PMC - PubMed

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