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Comment
. 2018 Feb;8(2):137.
doi: 10.1158/2159-8290.CD-RW2017-240. Epub 2017 Dec 21.

R-2HG Targets FTO to Increase m6A Levels and Suppress Tumor Growth

No authors listed
Comment

R-2HG Targets FTO to Increase m6A Levels and Suppress Tumor Growth

No authors listed. Cancer Discov. 2018 Feb.

Abstract

R-2HG, thought to be an oncometabolite in IDH-mutant tumors, has antitumor activity in leukemia and glioma.

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  • R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
    Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J. Su R, et al. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14. Cell. 2018. PMID: 29249359 Free PMC article.

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