Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec 22;23(1):7.
doi: 10.3390/molecules23010007.

Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency

Virginie Aires  1   2 , Dominique Delmas  3   4 , Fatima Djouadi  5 , Jean Bastin  6 , Mustapha Cherkaoui-Malki  7 , Norbert Latruffe  8
Affiliations

Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency

Virginie Aires et al. Molecules. .

Abstract

Carnitine palmitoyltransferase-2 (CPT2) is a mitochondrial enzyme involved in long-chain fatty acid entry into mitochondria for their β-oxidation and energy production. Two phenotypes are associated with the extremely reduced CPT2 activity in genetically deficient patients: neonatal lethality or, in milder forms, myopathy. Resveratrol (RSV) is a phytophenol produced by grape plant in response to biotic or abiotic stresses that displays anti-oxidant properties, in particular through AP-1, NFκB, STAT-3, and COX pathways. Some beneficiary effects of RSV are due to its modulation of microRNA (miRNA) expression. RSV can enhance residual CPT2 activities in human fibroblasts derived from CPT2-deficient patients and restores normal fatty acid oxidation rates likely through stimulation of mitochondrial biogenesis. Here, we report changes in miRNA expression linked to CPT2-deficiency, and we identify miRNAs whose expression changed following RSV treatment of control or CPT2-deficient fibroblasts isolated from patients. Our findings suggest that RSV consumption might exert beneficiary effects in patients with CPT2-deficiency.

Keywords: CPT2-deficient cells; miRNA level; resveratrol.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Latruffe N., Rifler J.-P. Bioactive polyphenols from grape and wine. Curr. Pharm. Des. 2013;19:6053–6063. doi: 10.2174/1381612811319340002. - DOI - PubMed
    1. Jeandet P., Delaunois B., Conreux A., Donnez D., Nuzzo V., Cordelier S., Clément C., Courot E. Biosynthesis, metabolism, molecular engineering, and biological functions of stilbene phytoalexins in plants. BioFactors. 2010;36:331–341. doi: 10.1002/biof.108. - DOI - PubMed
    1. Jeandet P., Hébrard C., Deville M.A., Cordelier S., Dorey S., Aziz A., Crouzet J. Deciphering the role of phytoalexins in plant-microorganism interactions and human health. Molecules. 2014;19:18033–18056. doi: 10.3390/molecules191118033. - DOI - PMC - PubMed
    1. Tili E., Michaille J.J., Adair B., Alder H., Limagne E., Taccioli C., Ferracin M., Delmas D., Latruffe N., Croce C.M. Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD. Carcinogenesis. 2010;31:1561–1566. doi: 10.1093/carcin/bgq143. - DOI - PMC - PubMed
    1. Limagne E., Lançon A., Delmas D., Cherkaoui-Malki M., Latruffe N. Resveratrol Interferes with IL1-β-Induced Pro-Inflammatory Paracrine Interaction between Primary Chondrocytes and Macrophages. Nutrients. 2016;8:280. doi: 10.3390/nu8050280. - DOI - PMC - PubMed

MeSH terms

Supplementary concepts

LinkOut - more resources